Stefanie N Hinkle1, Alicia M Johns2, Paul S Albert2, Sungduk Kim2, Katherine L Grantz3. 1. Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Electronic address: hinklesn@mail.nih.gov. 2. Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. 3. Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Abstract
OBJECTIVE: Total pregnancy weight gain has been associated with infant birthweight; however, most prior studies lacked repeat ultrasound measurements. Understanding of the longitudinal changes in maternal weight gain and intrauterine changes in fetal anthropometrics is limited. STUDY DESIGN: Prospective data from 1314 Scandinavian singleton pregnancies at high-risk for delivering small-for-gestational-age (SGA) were analyzed. Women had ≥1 (median 12) antenatal weight measurements. Ultrasounds were targeted at 17, 25, 33, and 37 weeks of gestation. Analyses involved a multi-step process. First, trajectories were estimated across gestation for maternal weight gain and fetal biometrics [abdominal circumference (AC, mm), biparietal diameter (BPD, mm), femur length (FL, mm), and estimated fetal weight (EFW, g)] using linear mixed models. Second, the association between maternal weight changes (per 5 kg) and corresponding fetal growth from 0 to 17, 17 to 28, and 28 to 37 weeks was estimated for each fetal parameter adjusting for prepregnancy body mass index, height, parity, chronic diseases, age, smoking, fetal sex, and weight gain up to the respective period as applicable. Third, the probability of fetal SGA, EFW <10th percentile, at the 3rd ultrasound was estimated across the spectrum of maternal weight gain rate by SGA status at the 2nd ultrasound. RESULTS: From 0 to 17 weeks, changes in maternal weight were most strongly associated with changes in BPD [β=0.51 per 5 kg (95%CI 0.26, 0.76)] and FL [β=0.46 per 5 kg (95%CI 0.26, 0.65)]. From 17 to 28 weeks, AC [β=2.92 per 5 kg (95%CI 1.62, 4.22)] and EFW [β=58.7 per 5 kg (95%CI 29.5, 88.0)] were more strongly associated with changes in maternal weight. Increased maternal weight gain was significantly associated with a reduced probability of intrauterine SGA; for a normal weight woman with SGA at the 2nd ultrasound, the probability of fetal SGA with a weight gain rate of 0.29 kg/w (10th percentile) was 59%, compared to 38% with a rate of 0.67 kg/w (90th percentile). CONCLUSION: Among women at high-risk for SGA, maternal weight gain was associated with fetal growth throughout pregnancy, but had a differential relationship with specific biometrics across gestation. For women with fetal SGA identified mid-pregnancy, increased antenatal weight gain was associated with a decreased probability of fetal SGA approximately 7 weeks later.
OBJECTIVE: Total pregnancy weight gain has been associated with infant birthweight; however, most prior studies lacked repeat ultrasound measurements. Understanding of the longitudinal changes in maternal weight gain and intrauterine changes in fetal anthropometrics is limited. STUDY DESIGN: Prospective data from 1314 Scandinavian singleton pregnancies at high-risk for delivering small-for-gestational-age (SGA) were analyzed. Women had ≥1 (median 12) antenatal weight measurements. Ultrasounds were targeted at 17, 25, 33, and 37 weeks of gestation. Analyses involved a multi-step process. First, trajectories were estimated across gestation for maternal weight gain and fetal biometrics [abdominal circumference (AC, mm), biparietal diameter (BPD, mm), femur length (FL, mm), and estimated fetal weight (EFW, g)] using linear mixed models. Second, the association between maternal weight changes (per 5 kg) and corresponding fetal growth from 0 to 17, 17 to 28, and 28 to 37 weeks was estimated for each fetal parameter adjusting for prepregnancy body mass index, height, parity, chronic diseases, age, smoking, fetal sex, and weight gain up to the respective period as applicable. Third, the probability of fetal SGA, EFW <10th percentile, at the 3rd ultrasound was estimated across the spectrum of maternal weight gain rate by SGA status at the 2nd ultrasound. RESULTS: From 0 to 17 weeks, changes in maternal weight were most strongly associated with changes in BPD [β=0.51 per 5 kg (95%CI 0.26, 0.76)] and FL [β=0.46 per 5 kg (95%CI 0.26, 0.65)]. From 17 to 28 weeks, AC [β=2.92 per 5 kg (95%CI 1.62, 4.22)] and EFW [β=58.7 per 5 kg (95%CI 29.5, 88.0)] were more strongly associated with changes in maternal weight. Increased maternal weight gain was significantly associated with a reduced probability of intrauterine SGA; for a normal weight woman with SGA at the 2nd ultrasound, the probability of fetal SGA with a weight gain rate of 0.29 kg/w (10th percentile) was 59%, compared to 38% with a rate of 0.67 kg/w (90th percentile). CONCLUSION: Among women at high-risk for SGA, maternal weight gain was associated with fetal growth throughout pregnancy, but had a differential relationship with specific biometrics across gestation. For women with fetal SGA identified mid-pregnancy, increased antenatal weight gain was associated with a decreased probability of fetal SGA approximately 7 weeks later.
Authors: Claire E Margerison-Zilko; Bina P Shrimali; Brenda Eskenazi; Maureen Lahiff; Allison R Lindquist; Barbara F Abrams Journal: Matern Child Health J Date: 2012-08
Authors: Alexis Jayne Hure; Clare Elizabeth Collins; Warwick Bruce Giles; Jonathan Winter Paul; Roger Smith Journal: Matern Child Health J Date: 2012-10
Authors: Michelle L Blumfield; Alexis J Hure; Lesley K MacDonald-Wicks; Roger Smith; Stephen J Simpson; Warwick B Giles; David Raubenheimer; Clare E Collins Journal: Am J Clin Nutr Date: 2012-10-03 Impact factor: 7.045
Authors: Sabine J Roza; Eric A P Steegers; Bero O Verburg; Vincent W V Jaddoe; Henriette A Moll; Albert Hofman; Frank C Verhulst; Henning Tiemeier Journal: Am J Epidemiol Date: 2008-09-30 Impact factor: 4.897
Authors: Julie Johnson; Rebecca G Clifton; James M Roberts; Leslie Myatt; John C Hauth; Catherine Y Spong; Michael W Varner; Ronald J Wapner; John M Thorp; Brian M Mercer; Alan M Peaceman; Susan M Ramin; Philip Samuels; Anthony Sciscione; Margaret Harper; Jorge E Tolosa; George Saade; Yoram Sorokin Journal: Obstet Gynecol Date: 2013-05 Impact factor: 7.661
Authors: Danielle R Stevens; William Grobman; Rajesh Kumar; Leah M Lipsky; Stefanie N Hinkle; Zhen Chen; Andrew Williams; Matthew C H Rohn; Jenna Kanner; Seth Sherman; Pauline Mendola Journal: Am J Epidemiol Date: 2021-05-04 Impact factor: 4.897
Authors: Stephanie V Wrottesley; Alessandra Prioreschi; Sarah H Kehoe; Kate A Ward; Shane A Norris Journal: Matern Child Nutr Date: 2019-11-27 Impact factor: 3.092
Authors: Anne Marie Darling; Martha M Werler; David E Cantonwine; Wafaie W Fawzi; Thomas F McElrath Journal: Epidemiology Date: 2019-09 Impact factor: 4.822
Authors: Sarah J Pugh; Stefanie N Hinkle; Sungduk Kim; Paul S Albert; Roger Newman; William A Grobman; Deborah A Wing; Katherine L Grantz Journal: J Ultrasound Med Date: 2017-09-29 Impact factor: 2.153