| Literature DB >> 25977790 |
Brian D Aevermann1, Brett E Pickett1, Sanjeev Kumar2, Edward B Klem2, Sudhakar Agnihothram3, Peter S Askovich4, Armand Bankhead5, Meagen Bolles6, Victoria Carter7, Jean Chang7, Therese R W Clauss8, Pradyot Dash9, Alan H Diercks4, Amie J Eisfeld10, Amy Ellis10, Shufang Fan10, Martin T Ferris11, Lisa E Gralinski6, Richard R Green7, Marina A Gritsenko8, Masato Hatta10, Robert A Heegel8, Jon M Jacobs8, Sophia Jeng12, Laurence Josset7, Shari M Kaiser4, Sara Kelly7, G Lynn Law7, Chengjun Li13, Jiangning Li4, Casey Long3, Maria L Luna8, Melissa Matzke8, Jason McDermott8, Vineet Menachery3, Thomas O Metz8, Hugh Mitchell8, Matthew E Monroe8, Garnet Navarro4, Gabriele Neumann10, Rebecca L Podyminogin4, Samuel O Purvine14, Carrie M Rosenberger4, Catherine J Sanders9, Athena A Schepmoes8, Anil K Shukla8, Amy Sims3, Pavel Sova7, Vincent C Tam4, Nicolas Tchitchek7, Paul G Thomas9, Susan C Tilton8, Allison Totura6, Jing Wang8, Bobbie-Jo Webb-Robertson8, Ji Wen8, Jeffrey M Weiss7, Feng Yang8, Boyd Yount3, Qibin Zhang8, Shannon McWeeney5, Richard D Smith8, Katrina M Waters8, Yoshihiro Kawaoka10, Ralph Baric15, Alan Aderem4, Michael G Katze16, Richard H Scheuermann17.
Abstract
The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that investigate in vivo and in vitro host responses to viral infections. Human pathogens in the Orthomyxoviridae and Coronaviridae families, especially pandemic H1N1 and avian H5N1 influenza A viruses and severe acute respiratory syndrome coronavirus (SARS-CoV), were investigated. Study validation was demonstrated via experimental quality control measures and meta-analysis of independent experiments performed under similar conditions. Primary assay results are archived at the GEO and PeptideAtlas public repositories, while processed statistical results together with standardized metadata are publically available at the Influenza Research Database (www.fludb.org) and the Virus Pathogen Resource (www.viprbrc.org). By comparing data from mutant versus wild-type virus and host strains, RNA versus protein differential expression, and infection with genetically similar strains, these data can be used to further investigate genetic and physiological determinants of host responses to viral infection.Entities:
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Year: 2014 PMID： 25977790 PMCID： PMC4410982 DOI： 10.1038/sdata.2014.33
Source DB: PubMed Journal: Sci Data ISSN： 2052-4463 Impact factor: 6.444