Maria Caterina Pace1, Maria Beatrice Passavanti1, Caterina Aurilio1, Pasquale Sansone1, Rossella Aurilio1, Salvatore DE Maria2, Stefania Lama3, Alessandro Federico4, Gianpietro Ravagnan2, Michele Caraglia5, Paola Stiuso5. 1. Department of Anesthesiological, Surgical and Emergency Sciences, Second University of Naples, Naples, Italy. 2. Department of Operative Units-Naples GLURES srl, Second University of Naples, Naples, Italy. 3. Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy. 4. Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy. 5. Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy Michele.caraglia@unina2.it paola.stiuso@unina2.it.
Abstract
AIM: Polydatin, a hydroxystilbene derived from the rhizome of Polygonum cuspidatum, elicits hepatoprotective and neuroprotective effects through its anti-oxidant properties. The present study aimed to determine the effects of oral administration of polydatin in alcoholic patients in order to improve liver biochemical parameters, serum oxidative stress and mental state. We enrolled 20 chronic alcoholic patients hospitalized for rehabilitative therapy. The patients were divided into two groups receiving the following treatment regimes for two weeks: administration of an anti-oxidant nutritional supplement containing glutathione and vitamin C (group 1), or glutathione, vitamin C and polydatin (group 2). RESULTS: The results of the present study show that elevated plasma aspartate aminotransferase and alanine aminotransferase levels in patients after two weeks of alcohol withdrawal were significantly reduced by polydatin (group 2), when compared to group 1. Polydatin also significantly reduced lipid peroxidation levels. Finally, our preliminary data resulting from the analysis of the Mini-Mental Status suggest that polydatin improves cognitive performance. CONCLUSION: Daily dietary administration of polydatin should be considered for prevention and treatment of liver disease and cognitive impairment in alcoholic patients.
AIM: Polydatin, a hydroxystilbene derived from the rhizome of Polygonum cuspidatum, elicits hepatoprotective and neuroprotective effects through its anti-oxidant properties. The present study aimed to determine the effects of oral administration of polydatin in alcoholicpatients in order to improve liver biochemical parameters, serum oxidative stress and mental state. We enrolled 20 chronic alcoholicpatients hospitalized for rehabilitative therapy. The patients were divided into two groups receiving the following treatment regimes for two weeks: administration of an anti-oxidant nutritional supplement containing glutathione and vitamin C (group 1), or glutathione, vitamin C and polydatin (group 2). RESULTS: The results of the present study show that elevated plasma aspartate aminotransferase and alanine aminotransferase levels in patients after two weeks of alcohol withdrawal were significantly reduced by polydatin (group 2), when compared to group 1. Polydatin also significantly reduced lipid peroxidation levels. Finally, our preliminary data resulting from the analysis of the Mini-Mental Status suggest that polydatin improves cognitive performance. CONCLUSION: Daily dietary administration of polydatin should be considered for prevention and treatment of liver disease and cognitive impairment in alcoholicpatients.
Authors: Adriana Di Benedetto; Francesca Posa; Salvatore De Maria; Giampietro Ravagnan; Andrea Ballini; Chiara Porro; Teresa Trotta; Maria Grano; Lorenzo Lo Muzio; Giorgio Mori Journal: Int J Med Sci Date: 2018-06-13 Impact factor: 3.738