Literature DB >> 2597675

Structure of the low-density lipoprotein receptor-related protein (LRP) promoter.

H Kütt1, J Herz, K K Stanley.   

Abstract

The low-density Lipoprotein receptor-related protein (LRP) is a 4544-amino-acid membrane protein which closely resembles the LDL receptor in its arrangement of cysteine-rich motifs. Binding studies have suggested that one function of the molecule is as a receptor for ligands containing apolipoprotein E. We present here the sequence and structure of the promoter region of the LRP. These data show that the LRP contains no sterol regulatory element, and is not down-regulated by sterols like the LDL receptor. This lends further support to the identity of the LRP as a chylomicron remnant receptor.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2597675     DOI： 10.1016/0167-4781(89)90107-3

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  10 in total

1.  Effect of dietary cholesterol on low density lipoprotein-receptor, 3-hydroxy-3-methylglutaryl-CoA reductase, and low density lipoprotein receptor-related protein mRNA expression in healthy humans.

Authors:  P Boucher; M de Lorgeril; P Salen; P Crozier; J Delaye; J J Vallon; A Geyssant; R Dante
Journal:  Lipids       Date:  1998-12       Impact factor: 1.880

2.  Aging alters mRNA expression of amyloid transporter genes at the blood-brain barrier.

Authors:  Doreen Osgood; Miles C Miller; Arthur A Messier; Liliana Gonzalez; Gerald D Silverberg
Journal:  Neurobiol Aging       Date:  2017-05-19       Impact factor: 4.673

3.  LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells.

Authors:  Salman Azhar; Satyanarayana Medicherla; Wen-Jun Shen; Yoshio Fujioka; Loren G Fong; Eve Reaven; Allen D Cooper
Journal:  J Lipid Res       Date:  2006-08-23       Impact factor: 5.922

4.  Lipoprotein lipase- and hepatic triglyceride lipase- promoted very low density lipoprotein degradation proceeds via an apolipoprotein E-dependent mechanism.

Authors:  J D Medh; G L Fry; S L Bowen; S Ruben; H Wong; D A Chappell
Journal:  J Lipid Res       Date:  2000-11       Impact factor: 5.922

5.  Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.

Authors:  H Shimano; N Yamada; M Katsuki; M Shimada; T Gotoda; K Harada; T Murase; C Fukazawa; F Takaku; Y Yazaki
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205

Review 6.  Dynamics of hepatic and intestinal cholesterol and bile acid pathways: The impact of the animal model of estrogen deficiency and exercise training.

Authors:  Jean-Marc Lavoie
Journal:  World J Hepatol       Date:  2016-08-18

7.  Modulation of the low-density-lipoprotein-receptor-related protein and its relevance to chylomicron-remnant metabolism.

Authors:  A Szanto; S Balasubramaniam; P D Roach; P J Nestel
Journal:  Biochem J       Date:  1992-12-15       Impact factor: 3.857

8.  Expression and regulation of apolipoprotein E receptors in the cells of the central nervous system in culture: A review.

Authors:  Q W Fan; I Iosbe; H Asou; K Yanagisawa; M Michikawa
Journal:  J Am Aging Assoc       Date:  2001-01

9.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1990-03-11       Impact factor: 16.971

10.  Impaired adult hippocampal neurogenesis in a mouse model of familial hypercholesterolemia: A role for the LDL receptor and cholesterol metabolism in adult neural precursor cells.

Authors:  Daiane F Engel; Anna N Grzyb; Jade de Oliveira; Alexandra Pötzsch; Tara L Walker; Patricia S Brocardo; Gerd Kempermann; Andreza F de Bem
Journal:  Mol Metab       Date:  2019-09-11       Impact factor: 7.422
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.