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Literature DB >> 25976680

Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology.

Pengli Zheng¹, Qiao Wang¹, Junlin Teng¹, Jianguo Chen².

Abstract

Tumor metastasis is a key cause of cancer mortality, and inhibiting migration of cancer cells is one of the major directions of anti-metastatic drug development. Calumenin and fibulin-1 are two extracellular proteins that synergistically inhibit cell migration and tumor metastasis, and could potentially be served as targets for pharmacological research of anti-metastatic drugs. This review briefly introduces the multi-function of these two proteins, and discusses the mechanism of how they regulate cell migration and tumor metastasis.

Entities: Disease Gene

Keywords: Anti-metastasis; Calumenin; Cell migration; Fibulin-1

Mesh：

Substances：

Year: 2015 PMID： 25976680 DOI： 10.1016/j.phrs.2015.05.001

Source DB: PubMed Journal: Pharmacol Res ISSN： 1043-6618 Impact factor: 7.658

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Cited

6 in total

1. USP6 activation in nodular fasciitis by promoter-swapping gene fusions.

Authors: Nimesh R Patel; John S A Chrisinger; Elizabeth G Demicco; Stephen F Sarabia; Jacquelyn Reuther; Erica Kumar; Andre M Oliveira; Steven D Billings; Judith V M G Bovée; Angshumoy Roy; Alexander J Lazar; Dolores H Lopez-Terrada; Wei-Lien Wang
Journal: Mod Pathol Date: 2017-07-28 Impact factor: 7.842

2. Genome-wide gain-of-function screen for genes that induce epithelial-to-mesenchymal transition in breast cancer.

Authors: Dubravka Škalamera; Mareike Dahmer-Heath; Alexander J Stevenson; Cletus Pinto; Esha T Shah; Sheena M Daignault; Nur Akmarina B M Said; Melissa Davis; Nikolas K Haass; Elizabeth D Williams; Brett G Hollier; Erik W Thompson; Brian Gabrielli; Thomas J Gonda
Journal: Oncotarget Date: 2016-09-20

Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology.

1. USP6 activation in nodular fasciitis by promoter-swapping gene fusions.

2. Genome-wide gain-of-function screen for genes that induce epithelial-to-mesenchymal transition in breast cancer.

3. Quantitative proteomics approach reveals novel biomarkers and pathological mechanism of keloid.

4. Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes.

5. MicroRNA-21 in cancer-associated fibroblasts supports lung adenocarcinoma progression.

6. Calumenin contributes to epithelial-mesenchymal transition and predicts poor survival in glioma.