Ricarda Evens1, Yuliya Stankevich2, Maja Dshemuchadse3, Alexander Storch4, Martin Wolz5, Heinz Reichmann4, Thomas E Schlaepfer6, Thomas Goschke3, Ulrike Lueken2. 1. Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany. Electronic address: ricarda.evens@tu-dresden.de. 2. Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany. 3. Department of Psychology, Technische Universität Dresden, Dresden, Germany. 4. Department of Neurology, Technische Universität Dresden, Dresden, Germany. 5. Department of Neurology, Elblandklinikum, Meissen, Germany. 6. Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany; Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Baltimore, USA.
Abstract
BACKGROUND: Due to its position in cortico-subthalamic and cortico-striatal pathways, the subthalamic nucleus (STN) is considered to play a crucial role not only in motor, but also in cognitive and motivational functions. In the present study we aimed to characterize how different aspects of reward processing are affected by disease and deep brain stimulation of the STN (DBS-STN) in patients with idiopathic Parkinson's disease (PD). METHODS: We compared 33 PD patients treated with DBS-STN under best medical treatment (DBS-on, medication-on) to 33 PD patients without DBS, but optimized pharmacological treatment and 34 age-matched healthy controls. We then investigated DBS-STN effects using a postoperative stimulation-on/ -off design. The task set included a delay discounting task, a task to assess changes in incentive salience attribution, and the Iowa Gambling Task. RESULTS: The presence of PD was associated with increased incentive salience attribution and devaluation of delayed rewards. Acute DBS-STN increased risky choices in the Iowa Gambling Task under DBS-on condition, but did not further affect incentive salience attribution or the evaluation of delayed rewards. CONCLUSION: Findings indicate that acute DBS-STN affects specific aspects of reward processing, including the weighting of gains and losses, while larger-scale effects of disease or medication are predominant in others reward-related functions.
BACKGROUND: Due to its position in cortico-subthalamic and cortico-striatal pathways, the subthalamic nucleus (STN) is considered to play a crucial role not only in motor, but also in cognitive and motivational functions. In the present study we aimed to characterize how different aspects of reward processing are affected by disease and deep brain stimulation of the STN (DBS-STN) in patients with idiopathic Parkinson's disease (PD). METHODS: We compared 33 PDpatients treated with DBS-STN under best medical treatment (DBS-on, medication-on) to 33 PDpatients without DBS, but optimized pharmacological treatment and 34 age-matched healthy controls. We then investigated DBS-STN effects using a postoperative stimulation-on/ -off design. The task set included a delay discounting task, a task to assess changes in incentive salience attribution, and the Iowa Gambling Task. RESULTS: The presence of PD was associated with increased incentive salience attribution and devaluation of delayed rewards. Acute DBS-STN increased risky choices in the Iowa Gambling Task under DBS-on condition, but did not further affect incentive salience attribution or the evaluation of delayed rewards. CONCLUSION: Findings indicate that acute DBS-STN affects specific aspects of reward processing, including the weighting of gains and losses, while larger-scale effects of disease or medication are predominant in others reward-related functions.
Authors: Justin R Yates; Benjamin T Gunkel; Katherine K Rogers; Mallory N Hughes; Nicholas A Prior Journal: Psychopharmacology (Berl) Date: 2016-11-11 Impact factor: 4.530
Authors: Rita Pasion; Ana R Gonçalves; Carina Fernandes; Fernando Ferreira-Santos; Fernando Barbosa; João Marques-Teixeira Journal: Front Psychol Date: 2017-10-11
Authors: Thomas J C Zoon; Geeske van Rooijen; Georgina M F C Balm; Isidoor O Bergfeld; Joost G Daams; Paul Krack; Damiaan A J P Denys; Rob M A de Bie Journal: Mov Disord Date: 2020-12-16 Impact factor: 10.338