Literature DB >> 25975755

An expression system for Gustatory receptors - and why it failed.

Hubert Amrein1.   

Abstract

A recent paper by the Dahankuar laboratory suggested that single Drosophila sugar receptors proteins accurately mediate sugar detection when ectopically expressed in olfactory neurons of the antenna. These findings contra-dict numerous previously published electrophysiological and behavioral investigations, which all point towards heteromultimeric sugar taste receptors. Here, I provide some explanation why this "pseudo-heterologous" expression system may have led to this misleading conclusion.

Entities:  

Keywords:  Gr Genes; expression system; heterodimers; olfactony learning and memory; olfactory neuron; taste receptors

Mesh：

Substances：

Year:  2014        PMID： 25975755      PMCID： PMC4594606          DOI： 10.1080/19336934.2015.1039756

Source DB:  PubMed          Journal:  Fly (Austin)        ISSN： 1933-6934            Impact factor:   2.160


  12 in total

1.  Atypical expression of Drosophila gustatory receptor genes in sensory and central neurons.

Authors:  Natasha Thorne; Hubert Amrein
Journal:  J Comp Neurol       Date:  2008-02-01       Impact factor: 3.215

2.  Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensing.

Authors:  Shinsuke Fujii; Ahmet Yavuz; Jesse Slone; Christopher Jagge; Xiangyu Song; Hubert Amrein
Journal:  Curr Biol       Date:  2015-02-19       Impact factor: 10.834

3.  Two chemosensory receptors together mediate carbon dioxide detection in Drosophila.

Authors:  Walton D Jones; Pelin Cayirlioglu; Ilona Grunwald Kadow; Leslie B Vosshall
Journal:  Nature       Date:  2006-12-13       Impact factor: 49.962

4.  A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging.

Authors:  Yuchen Jiao; Seok Jun Moon; Craig Montell
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-22       Impact factor: 11.205

5.  Two Gr genes underlie sugar reception in Drosophila.

Authors:  Anupama Dahanukar; Ya-Ting Lei; Jae Young Kwon; John R Carlson
Journal:  Neuron       Date:  2007-11-08       Impact factor: 17.173

6.  A sugar gustatory receptor identified from the foregut of cotton bollworm Helicoverpa armigera.

Authors:  Wei Xu; Hui-Jie Zhang; Alisha Anderson
Journal:  J Chem Ecol       Date:  2012-12-06       Impact factor: 2.626

7.  Sugar receptors in Drosophila.

Authors:  Jesse Slone; Joseph Daniels; Hubert Amrein
Journal:  Curr Biol       Date:  2007-10-04       Impact factor: 10.834

8.  The molecular basis of CO2 reception in Drosophila.

Authors:  Jae Young Kwon; Anupama Dahanukar; Linnea A Weiss; John R Carlson
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-20       Impact factor: 11.205

9.  Detection of sweet tastants by a conserved group of insect gustatory receptors.

Authors:  Erica Gene Freeman; Zev Wisotsky; Anupama Dahanukar
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-13       Impact factor: 11.205

10.  Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila.

Authors:  Yuchen Jiao; Seok Jun Moon; Xiaoyue Wang; Qiuting Ren; Craig Montell
Journal:  Curr Biol       Date:  2008-11-25       Impact factor: 10.834
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  1 in total

1.  Genome of the small hive beetle (Aethina tumida, Coleoptera: Nitidulidae), a worldwide parasite of social bee colonies, provides insights into detoxification and herbivory.

Authors:  Jay D Evans; Duane McKenna; Erin Scully; Steven C Cook; Benjamin Dainat; Noble Egekwu; Nathaniel Grubbs; Dawn Lopez; Marcé D Lorenzen; Steven M Reyna; Frank D Rinkevich; Peter Neumann; Qiang Huang
Journal:  Gigascience       Date:  2018-12-01       Impact factor: 6.524
  1 in total

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