GOAL: Earlier studies have documented that coronary artery disease (CAD) produces weak murmurs, which might be detected through analysis of heart sounds. An electronic stethoscope with a digital signal processing unit could be a low cost and easily applied method for diagnosis of CAD. The current study is a search for heart sound features which might identify CAD. METHODS: Nine different types of features from five overlapping frequency bands were obtained and analyzed using 435 recordings from 133 subjects. RESULTS: New features describing an increase in low-frequency power in CAD patients were identified. The features of the different types were relatively strongly correlated. Using a quadratic discriminant function, multiple features were combined into a CAD-score. The area under the receiving operating characteristic for the CAD score was 0.73 (95% CI: 0.69-0.78). CONCLUSION: The result confirms that there is a potential in heart sounds for the diagnosis of CAD, but that further improvements are necessary to gain clinical relevance.
GOAL: Earlier studies have documented that coronary artery disease (CAD) produces weak murmurs, which might be detected through analysis of heart sounds. An electronic stethoscope with a digital signal processing unit could be a low cost and easily applied method for diagnosis of CAD. The current study is a search for heart sound features which might identify CAD. METHODS: Nine different types of features from five overlapping frequency bands were obtained and analyzed using 435 recordings from 133 subjects. RESULTS: New features describing an increase in low-frequency power in CAD patients were identified. The features of the different types were relatively strongly correlated. Using a quadratic discriminant function, multiple features were combined into a CAD-score. The area under the receiving operating characteristic for the CAD score was 0.73 (95% CI: 0.69-0.78). CONCLUSION: The result confirms that there is a potential in heart sounds for the diagnosis of CAD, but that further improvements are necessary to gain clinical relevance.
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Authors: Simon Winther; Louise Nissen; Samuel Emil Schmidt; Jelmer Sybren Westra; Laust Dupont Rasmussen; Lars Lyhne Knudsen; Lene Helleskov Madsen; Jane Kirk Johansen; Bjarke Skogstad Larsen; Johannes Jan Struijk; Lars Frost; Niels Ramsing Holm; Evald Høj Christiansen; Hans Erik Botker; Morten Bøttcher Journal: Heart Date: 2017-11-09 Impact factor: 5.994
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Authors: S E Schmidt; S Winther; B S Larsen; M H Groenhoej; L Nissen; J Westra; L Frost; N R Holm; H Mickley; F H Steffensen; J Lambrechtsen; M S Nørskov; J J Struijk; A C P Diederichsen; M Boettcher Journal: Int J Cardiovasc Imaging Date: 2019-07-04 Impact factor: 2.357
Authors: Louise Nissen; Simon Winther; Christin Isaksen; June Anita Ejlersen; Lau Brix; Grazina Urbonaviciene; Lars Frost; Lene Helleskov Madsen; Lars Lyhne Knudsen; Samuel Emil Schmidt; Niels Ramsing Holm; Michael Maeng; Mette Nyegaard; Hans Erik Bøtker; Morten Bøttcher Journal: Trials Date: 2016-05-26 Impact factor: 2.279
Authors: Simon Winther; Samuel Emil Schmidt; Niels Ramsing Holm; Egon Toft; Johannes Jan Struijk; Hans Erik Bøtker; Morten Bøttcher Journal: Int J Cardiovasc Imaging Date: 2015-09-03 Impact factor: 2.357