| Literature DB >> 2597432 |
S Misra1, T Sanyal, D Sarkar, P K Bhattacharya, D K Ghosh.
Abstract
TAA, an inhibitor of the enzyme aconitase, inhibits the growth of L. donovani promastigotes. Morphogenic transformation of the amastigote to the promastigote (table; see text) form in vitro was also inhibited by 2 mM TAA. TAA also reduced multiplication of the parasite in macrophage culture. In the hamster model of leishmania, TAA significantly reduced the parasitic burden of liver. In acute toxicity tests with BALB/c mice no deaths were recorded even at a dose level of 2 g/kg body wt/day.Entities:
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Year: 1989 PMID： 2597432 DOI： 10.1016/0885-4505(89)90052-2
Source DB: PubMed Journal: Biochem Med Metab Biol ISSN： 0885-4505