| Literature DB >> 25973305 |
Yanning Ma1, Yongfang Yue1, Min Pan1, Jie Sun1, Jue Chu1, Xiaoying Lin1, Wenxia Xu1, Lifeng Feng1, Yan Chen2, Dingwei Chen1, Vivian Y Shin3, Xian Wang1, Hongchuan Jin1.
Abstract
Cancer epigenetics plays an important role in the pathogenesis of many cancers including gastric cancer. Histone deacetylases (HDACs) emerge as exciting therapeutic targets for cancer treatment and prevention. In this study, we identified DTWD1 as one of the 122 genes upregulated after treatment of trichostatin A (TSA) in two gastric cancer cell lines. Moreover, DTWD1 was downregulated in gastric cancer cell lines and primary gastric carcinoma tissues. It was further identified as the new target of p53. Then we revealed that HDAC3 downregulated DTWD1 by disrupting the interaction of p53 with DTWD1 promoter. Furthermore, DTWD1 functioned as a tumor suppressor by downregulating cyclin B1 expression to inhibit proliferation. In summary, as the new p53 target gene, DTWD1 was downregulated in gastric cancer by HDAC3 and acted as a novel tumor suppressor gene. Specific inhibitors of HDAC3 might be a new approach for gastric cancer treatment by activating DTWD1 expression.Entities:
Keywords: DTWD1; HDAC; gastric cancer; p53; tumor suppressor gene
Year: 2015 PMID： 25973305 PMCID： PMC4396045
Source DB: PubMed Journal: Am J Cancer Res ISSN： 2156-6976 Impact factor: 6.166