Jinghua Shan1, Lianmei Sun1, Dewei Wang2, Xiuhua Li2. 1. Department of Anesthesia, Affiliated Hospital of Weifang Medical University Weifang 261053, Shandong province, China. 2. Department of Anesthesia, Weifang Medical University Weifang 261053, Shandong province, China.
Abstract
BACKGROUND: There are a few reports regarding the comparison of these anesthetic agents, but previous studies mainly focus on the veterinary anesthesiology. Less attention has been focused comparing the effectiveness of these inhalational anesthetic agents in neurosurgery. This lack of interest is regretful particularly considering the fact that anesthetics during neurosurgery are an issue of extreme sensitivity and subtlety, where the cerebral oxygenation process plays a significant role in the neuroprotective mechanisms. OBJECTIVE: The purpose of this retrospective study is to contribute to the existing knowledge of the comparative studies of the volatile anesthetic agents such as isoflurane, sevoflurane and desflurane by evaluating the maintenance and emergence characteristics after volatile anesthetics-induced preconditioning with isoflurane, sevoflurane or desflurane for inpatient ischemia/reperfusion cerebral injury during cerebral or neural surgeries. METHODS: The aim was to investigate their neuroprotective mechanisms and effects by analyzing and comparing the superiority of each agent in a Chinese patient population, in terms of faster emergence, and early and intermediate recovery. The intraoperative haemodynamic profiles and postoperative adverse effects of these three agents were also systematically analyzed. RESULTS: We found that sevoflurane, when compared with isoflurane and desflurane, provided anesthesia with similar hemodynamic stability but allowed for a smoother, more rapid emergence and better quality of induction and recovery to surgical patients under clinical conditions, particularly to those who were experiencing substantial cerebral vasodilation. CONCLUSION:Sevoflurane offers several advantages, including a relative lack of airway irritation, a more rapid onset and recovery, and greater hemodynamic stability than other potent inhaled agents. These properties would appear to afford sevoflurane significant clinical potential.
RCT Entities:
BACKGROUND: There are a few reports regarding the comparison of these anesthetic agents, but previous studies mainly focus on the veterinary anesthesiology. Less attention has been focused comparing the effectiveness of these inhalational anesthetic agents in neurosurgery. This lack of interest is regretful particularly considering the fact that anesthetics during neurosurgery are an issue of extreme sensitivity and subtlety, where the cerebral oxygenation process plays a significant role in the neuroprotective mechanisms. OBJECTIVE: The purpose of this retrospective study is to contribute to the existing knowledge of the comparative studies of the volatile anesthetic agents such as isoflurane, sevoflurane and desflurane by evaluating the maintenance and emergence characteristics after volatile anesthetics-induced preconditioning with isoflurane, sevoflurane or desflurane for inpatient ischemia/reperfusion cerebral injury during cerebral or neural surgeries. METHODS: The aim was to investigate their neuroprotective mechanisms and effects by analyzing and comparing the superiority of each agent in a Chinese patient population, in terms of faster emergence, and early and intermediate recovery. The intraoperative haemodynamic profiles and postoperative adverse effects of these three agents were also systematically analyzed. RESULTS: We found that sevoflurane, when compared with isoflurane and desflurane, provided anesthesia with similar hemodynamic stability but allowed for a smoother, more rapid emergence and better quality of induction and recovery to surgical patients under clinical conditions, particularly to those who were experiencing substantial cerebral vasodilation. CONCLUSION:Sevoflurane offers several advantages, including a relative lack of airway irritation, a more rapid onset and recovery, and greater hemodynamic stability than other potent inhaled agents. These properties would appear to afford sevoflurane significant clinical potential.
Authors: James M Sonner; Joseph F Antognini; Robert C Dutton; Pamela Flood; Andrew T Gray; R Adron Harris; Gregg E Homanics; Joan Kendig; Beverley Orser; Douglas E Raines; Ira J Rampil; James Trudell; Bryce Vissel; Edmond I Eger Journal: Anesth Analg Date: 2003-09 Impact factor: 5.108
Authors: Fun-Sun F Yao; Chia-Chih A Tseng; Chee-Yueh A Ho; Serle K Levin; Pavel Illner Journal: J Cardiothorac Vasc Anesth Date: 2004-10 Impact factor: 2.628
Authors: Thomas Schmoch; Christine Jungk; Thomas Bruckner; Sabine Haag; Klaus Zweckberger; Andreas von Deimling; Thorsten Brenner; Andreas Unterberg; Markus A Weigand; Florian Uhle; Christel Herold-Mende Journal: Neurosurg Rev Date: 2020-12-22 Impact factor: 3.042