| Literature DB >> 25973075 |
Song Mao1, Xiaoyan Xuan1, Yugen Sha1, Sanlong Zhao1, Aihua Zhang1, Songming Huang1.
Abstract
An eight-year-old girl, presenting with palpebral edema, gross hematuria, and foam in urine, was admitted to our hospital. Investigations indicated increased serum antistreptolysin O (ASO) and anti-mycoplasma antibody titers. Renal biopsy showed crescentic poststreptococcal acute glomerulonephritis (CPAGN) with isolated C3 deposition in the glomeruli. Electro-microscope examination showed subepithelial deposition of electron dense material. She received the double pulse therapies of methylprednisolone and cyclophosphamide as well as the treatment of oral prednisolone, angiotensin converting enzyme-II (ACE-II) inhibitor, dipyridamole and traditional Chinese medicine. The complete clinical remission was achieved after 9 months. No serious adverse effects were observed during the follow-up. Our findings indicated that CPAGN with isolated C3 deposition might have a favorable prognosis after aggressive immunosuppressive treatment. However, the influence of isolated C3 deposition on CPAGN prognosis remains to be clarified.Entities:
Keywords: C3; Crescentic poststreptococcal acute glomerulonephritis; deposition
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Year: 2015 PMID： 25973075 PMCID： PMC4396300
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625