Literature DB >> 25972406

Cross-Reactive Epitopes in Borrelia burgdorferi p66.

Paul M Arnaboldi1, Raymond J Dattwyler2.   

Abstract

Epitope mapping of the p66 outer membrane protein of Borrelia burgdorferi revealed that the protein contains numerous cross-reactive linear epitopes recognized by serum antibody in the majority of individuals tested, regardless of Lyme disease history, limiting the usefulness of this antigen in Lyme disease serodiagnostic assays.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25972406      PMCID： PMC4478522          DOI： 10.1128/CVI.00217-15

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  13 in total

1.  Decorin binding proteins A and B in the serodiagnosis of Lyme disease in North America.

Authors:  Paul M Arnaboldi; Mariya Sambir; Raymond J Dattwyler
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2.  Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease.

Authors: 
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3.  Delineation of Borrelia burgdorferi p66 sequences required for integrin alpha(IIb)beta(3) recognition.

Authors:  G Defoe; J Coburn
Journal:  Infect Immun       Date:  2001-05       Impact factor: 3.441

4.  Sensitive and specific serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant conserved region of Borrelia burgdorferi vlsE.

Authors:  F T Liang; A C Steere; A R Marques; B J Johnson; J N Miller; M T Philipp
Journal:  J Clin Microbiol       Date:  1999-12       Impact factor: 5.948

5.  Recognition of multiple antibody epitopes throughout Borrelia burgdorferi p66, a candidate adhesin, in patients with early or late manifestations of Lyme disease.

Authors:  H Ntchobo; H Rothermel; W Chege; A C Steere; J Coburn
Journal:  Infect Immun       Date:  2001-03       Impact factor: 3.441

6.  A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi.

Authors:  Alan G Barbour; Algimantas Jasinskas; Matthew A Kayala; D Huw Davies; Allen C Steere; Pierre Baldi; Philip L Felgner
Journal:  Infect Immun       Date:  2008-05-12       Impact factor: 3.441

7.  Regulation of expression of the Borrelia burgdorferi beta(3)-chain integrin ligand, P66, in ticks and in culture.

Authors:  Carla Cugini; Melisa Medrano; Tom G Schwan; Jenifer Coburn
Journal:  Infect Immun       Date:  2003-02       Impact factor: 3.441

8.  Outer surface protein C peptide derived from Borrelia burgdorferi sensu stricto as a target for serodiagnosis of early lyme disease.

Authors:  Paul M Arnaboldi; Rudra Seedarnee; Mariya Sambir; Steven M Callister; Josephine A Imparato; Raymond J Dattwyler
Journal:  Clin Vaccine Immunol       Date:  2013-01-30

9.  Identification of OppA2 linear epitopes as serodiagnostic markers for Lyme disease.

Authors:  Giacomo Signorino; Paul M Arnaboldi; Mary M Petzke; Raymond J Dattwyler
Journal:  Clin Vaccine Immunol       Date:  2014-03-12

10.  Diagnostic value of proteins of three Borrelia species (Borrelia burgdorferi sensu lato) and implications for development and use of recombinant antigens for serodiagnosis of Lyme borreliosis in Europe.

Authors:  U Hauser; G Lehnert; B Wilske
Journal:  Clin Diagn Lab Immunol       Date:  1998-07
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  7 in total

1.  Evaluation of a Novel Microarray Immunoblot Assay for Detection of IgM- and IgG-Class Antibodies to Borrelia burgdorferi.

Authors:  Elitza S Theel; Marisa Sorenson; Dane Granger
Journal:  J Clin Microbiol       Date:  2018-10-25       Impact factor: 5.948

2.  Delineating Surface Epitopes of Lyme Disease Pathogen Targeted by Highly Protective Antibodies of New Zealand White Rabbits.

Authors:  Artem S Rogovskyy; Salvador Eugenio C Caoili; Yurij Ionov; Helen Piontkivska; Pavel Skums; Viachaslau Tsyvina; Alex Zelikovsky; Suryakant D Waghela
Journal:  Infect Immun       Date:  2019-07-23       Impact factor: 3.441

3.  Development of a Multiantigen Panel for Improved Detection of Borrelia burgdorferi Infection in Early Lyme Disease.

Authors:  Lauren J Lahey; Michael W Panas; Rong Mao; Michelle Delanoy; John J Flanagan; Steven R Binder; Alison W Rebman; Jose G Montoya; Mark J Soloski; Allen C Steere; Raymond J Dattwyler; Paul M Arnaboldi; John N Aucott; William H Robinson
Journal:  J Clin Microbiol       Date:  2015-10-07       Impact factor: 5.948

Review 4.  Laboratory Diagnosis of Lyme Borreliosis.

Authors:  John A Branda; Allen C Steere
Journal:  Clin Microbiol Rev       Date:  2021-01-27       Impact factor: 26.132

5.  Precision medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1.

Authors:  Richard I Horowitz; Phyllis R Freeman
Journal:  Int J Gen Med       Date:  2019-02-18

6.  Linear B Cell Epitopes Derived from the Multifunctional Surface Lipoprotein BBK32 as Targets for the Serodiagnosis of Lyme Disease.

Authors:  Christina Toumanios; Lauren Prisco; Raymond J Dattwyler; Paul M Arnaboldi
Journal:  mSphere       Date:  2019-05-01       Impact factor: 4.389

7.  Linear Peptide Epitopes Derived from ErpP, p35, and FlaB in the Serodiagnosis of Lyme Disease.

Authors:  Paul M Arnaboldi; Adiya S Katseff; Mariya Sambir; Raymond J Dattwyler
Journal:  Pathogens       Date:  2022-08-20
  7 in total

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