Literature DB >> 25970806

Stressed SIRT7: facing a crossroad of senescence and immortality.

Jun-Ping Liu1,2, Ruping Chen1.   

Abstract

SIRT7 with coenzyme NAD catalyzes protein de-acetylation. In stress response, SIRT7 regulates protein folding in mitochondria with unknown mechanisms. Decreases in SIRT7 entrain hematopoietic stem cell senescence, but increasing SIRT7 causes elevation of hematopoietic stem cell regenerative function. We discuss the recent findings on SIRT7 and its binding proteins, NRF1 and GABPβ1, in decision making between the choices of inducing cell aging and immortality.
© 2015 Wiley Publishing Asia Pty Ltd.

Entities:  

Keywords:  ageing; cancer; hematopoietic stem cells; immortality; longevity; senescence

Mesh：

Substances：

Year:  2015        PMID： 25970806     DOI： 10.1111/1440-1681.12423

Source DB:  PubMed          Journal:  Clin Exp Pharmacol Physiol        ISSN： 0305-1870            Impact factor:   2.557


  6 in total

Review 1.  The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging.

Authors:  Jarmila Nahálková
Journal:  Mol Cell Biochem       Date:  2016-10-03       Impact factor: 3.396

2.  Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts.

Authors:  Anne E Wyman; Zahid Noor; Rita Fishelevich; Virginia Lockatell; Nirav G Shah; Nevins W Todd; Sergei P Atamas
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2017-04-06       Impact factor: 5.464

Review 3.  Sirtuins and Accelerated Aging in Scleroderma.

Authors:  Anne E Wyman; Sergei P Atamas
Journal:  Curr Rheumatol Rep       Date:  2018-03-17       Impact factor: 4.592

4.  SIRT7, H3K18ac, and ELK4 Immunohistochemical Expression in Hepatocellular Carcinoma.

Authors:  Hye Seung Lee; Wonkyung Jung; Eunjung Lee; Hyeyoon Chang; Jin Hyuk Choi; Han Gyeom Kim; Aeree Kim; Baek-Hui Kim
Journal:  J Pathol Transl Med       Date:  2016-08-05

5.  Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women.

Authors:  Karen Vrijens; Ellen Winckelmans; Maria Tsamou; Willy Baeyens; Patrick De Boever; Danyel Jennen; Theo M de Kok; Elly Den Hond; Wouter Lefebvre; Michelle Plusquin; Hans Reynders; Greet Schoeters; Nicolas Van Larebeke; Charlotte Vanpoucke; Jos Kleinjans; Tim S Nawrot
Journal:  Environ Health Perspect       Date:  2016-10-14       Impact factor: 9.031

Review 6.  A New Vision of Mitochondrial Unfolded Protein Response to the Sirtuin Family.

Authors:  Huidan Weng; Yihong Ma; Lina Chen; Guoen Cai; Zhiting Chen; Shaochuan Zhang; Qinyong Ye
Journal:  Curr Neuropharmacol       Date:  2020       Impact factor: 7.363
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.