| Literature DB >> 25970729 |
Jin-Hai Yu1, Guo-Cai Wang1, Ying-Shan Han2, Yan Wu1, Mark A Wainberg2, Jian-Min Yue1.
Abstract
Sixteen new limonoids, named ciparasins A-P (1-16), comprising three structural categories of trijugin-type (1-7), cipadesin-type (8-15), and prieurianin-type (16) compounds, as well as 15 known limonoid analogues (17-31), were isolated from Cipadessa cinerascens. Ciparasins E-G (5-7) were found to possess a rare γ-hydroxylbutenolide moiety at C-17. Ciparasins B (2) and P (16) showed significant anti-HIV activities, with EC50 values of 5.5 ± 0.6 (SI >7.2) and 6.1 ± 0.7 (SI >6.5) μM, respectively.Entities:
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Year: 2015 PMID： 25970729 DOI： 10.1021/acs.jnatprod.5b00025
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050