S A D Bejaimal1, C F Wu2, J Lowe1,3, D S Feig1,2,4,5,6, B R Shah1,2,3,5, L L Lipscombe1,2,5,7. 1. Department of Medicine, University of Toronto, Toronto, ON, Canada. 2. Institute for Clinical Evaluative Sciences, Toronto, ON, Canada. 3. Sunnybrook Health Sciences Centre, Toronto, ON, Canada. 4. Mount Sinai Hospital, Toronto, ON, Canada. 5. Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada. 6. Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada. 7. Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Abstract
AIMS: To evaluate the relationship between gestational diabetes (GDM) and incidence of cancer in women within the first decade postpartum. METHODS: This population-based retrospective cohort study compared the risk of cancer in women with GDM with that of a matched control group comprising pregnant women without diabetes. We included women from Ontario, Canada aged 20-50 years with no history of cancer who had given birth between 1995 and 2008 (N = 149 049). Women with GDM (N = 49 684) were matched on age and year of giving birth, in a ratio of 1:2, to pregnant women without diabetes (N = 99 365). RESULTS: Over a median 8-year follow-up, there were a total of 2927 (1.5%) cancers. After adjustment for covariates, we found no significant difference in overall risk of cancer between women with GDM and matched control subjects; however, GDM was associated with a significantly greater risk of thyroid cancer (adjusted hazard ratio 1.24, 95% CI 1.05, 1.46) and a significantly lower risk of premenopausal breast cancer (hazard ratio 0.86, 95% CI 0.75, 0.98) compared with matched control subjects. CONCLUSIONS: This large population-based study did not find a greater risk of cancers among women with GDM during the first decade postpartum; however, GDM was associated with a higher risk of thyroid cancer and a lower risk of premenopausal breast cancer. Further studies are needed to confirm these findings.
AIMS: To evaluate the relationship between gestational diabetes (GDM) and incidence of cancer in women within the first decade postpartum. METHODS: This population-based retrospective cohort study compared the risk of cancer in women with GDM with that of a matched control group comprising pregnant women without diabetes. We included women from Ontario, Canada aged 20-50 years with no history of cancer who had given birth between 1995 and 2008 (N = 149 049). Women with GDM (N = 49 684) were matched on age and year of giving birth, in a ratio of 1:2, to pregnant women without diabetes (N = 99 365). RESULTS: Over a median 8-year follow-up, there were a total of 2927 (1.5%) cancers. After adjustment for covariates, we found no significant difference in overall risk of cancer between women with GDM and matched control subjects; however, GDM was associated with a significantly greater risk of thyroid cancer (adjusted hazard ratio 1.24, 95% CI 1.05, 1.46) and a significantly lower risk of premenopausal breast cancer (hazard ratio 0.86, 95% CI 0.75, 0.98) compared with matched control subjects. CONCLUSIONS: This large population-based study did not find a greater risk of cancers among women with GDM during the first decade postpartum; however, GDM was associated with a higher risk of thyroid cancer and a lower risk of premenopausal breast cancer. Further studies are needed to confirm these findings.
Authors: Camille E Powe; Deirdre K Tobias; Karin B Michels; Wendy Y Chen; A Heather Eliassen; JoAnn E Manson; Bernard Rosner; Walter C Willett; Frank B Hu; Cuilin Zhang; Janet W Rich-Edwards; Kathryn M Rexrode Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-10-11 Impact factor: 4.254
Authors: Kimberly A Bertrand; Katie M O'Brien; Lauren B Wright; Julie R Palmer; William J Blot; A Heather Eliassen; Lynn Rosenberg; Sven Sandin; Deirdre Tobias; Elisabete Weiderpass; Wei Zheng; Anthony J Swerdlow; Minouk J Schoemaker; Hazel B Nichols; Dale P Sandler Journal: Int J Epidemiol Date: 2022-01-06 Impact factor: 7.196
Authors: Kimberly A Bertrand; Katie M O'Brien; Lauren B Wright; Julie R Palmer; William J Blot; A Heather Eliassen; Lynn Rosenberg; Sven Sandin; Deirdre Tobias; Elisabete Weiderpass; Wei Zheng; Anthony J Swerdlow; Minouk J Schoemaker; Hazel B Nichols; Dale P Sandler Journal: Int J Epidemiol Date: 2022-01-06 Impact factor: 9.685
Authors: Zahna Bigham; Yvonne Robles; Karen M Freund; Julie R Palmer; Kimberly A Bertrand Journal: Breast Cancer Res Treat Date: 2022-04-28 Impact factor: 4.624
Authors: Yong-Moon Mark Park; Katie M O'Brien; Shanshan Zhao; Clarice R Weinberg; Donna D Baird; Dale P Sandler Journal: Br J Cancer Date: 2017-02-16 Impact factor: 7.640