Literature DB >> 25970101

Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1).

Jiachi Chiou1, Shengbiao Wan, Kin-Fai Chan, Pui-Kin So, Dandan He, Edward Wai-chi Chan, Tak-hang Chan, Kwok-yin Wong, Jiang Tao, Sheng Chen.   

Abstract

We report the discovery of a promising NDM-1 inhibitor, ebselen, through a cell-based screening approach. Enzymatic kinetic study and ESI-MS analysis suggested that ebselen could bind to NDM-1 by forming a S-Se bond with the Cys(221) residue at the active site, thereby exhibiting a new inhibition mechanism with broad spectrum inhibitory potential.

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Year:  2015        PMID： 25970101     DOI： 10.1039/c5cc02594j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  26 in total

1.  Dithiocarbamate as a Valuable Scaffold for the Inhibition of Metallo-β-Lactmases.

Authors:  Ying Ge; Li-Wei Xu; Ya Liu; Le-Yun Sun; Han Gao; Jia-Qi Li; Kewu Yang
Journal:  Biomolecules       Date:  2019-11-05

2.  Investigation of Dipicolinic Acid Isosteres for the Inhibition of Metallo-β-Lactamases.

Authors:  Allie Y Chen; Pei W Thomas; Zishuo Cheng; Nasa Y Xu; David L Tierney; Michael W Crowder; Walter Fast; Seth M Cohen
Journal:  ChemMedChem       Date:  2019-05-24       Impact factor: 3.466

3.  A Lysine-Targeted Affinity Label for Serine-β-Lactamase Also Covalently Modifies New Delhi Metallo-β-lactamase-1 (NDM-1).

Authors:  Pei W Thomas; Michael Cammarata; Jennifer S Brodbelt; Arthur F Monzingo; R F Pratt; Walter Fast
Journal:  Biochemistry       Date:  2019-06-07       Impact factor: 3.162

4.  Rhodanine as a Potent Scaffold for the Development of Broad-Spectrum Metallo-β-lactamase Inhibitors.

Authors:  Yang Xiang; Cheng Chen; Wen-Ming Wang; Li-Wei Xu; Ke-Wu Yang; Peter Oelschlaeger; Yuan He
Journal:  ACS Med Chem Lett       Date:  2018-03-22       Impact factor: 4.345

Review 5.  Nanomaterial-Based Zinc Ion Interference Therapy to Combat Bacterial Infections.

Authors:  Yongbin Wei; Jiaming Wang; Sixuan Wu; Ruixue Zhou; Kaixiang Zhang; Zhenzhong Zhang; Junjie Liu; Shangshang Qin; Jinjin Shi
Journal:  Front Immunol       Date:  2022-06-30       Impact factor: 8.786

Review 6.  NDM Metallo-β-Lactamases and Their Bacterial Producers in Health Care Settings.

Authors:  Wenjing Wu; Yu Feng; Guangmin Tang; Fu Qiao; Alan McNally; Zhiyong Zong
Journal:  Clin Microbiol Rev       Date:  2019-01-30       Impact factor: 26.132

Review 7.  β-lactam/β-lactamase inhibitor combinations: an update.

Authors:  Kamaleddin H M E Tehrani; Nathaniel I Martin
Journal:  Medchemcomm       Date:  2018-08-17       Impact factor: 3.597

8.  Kinetic, Thermodynamic, and Crystallographic Studies of 2-Triazolylthioacetamides as Verona Integron-Encoded Metallo-β-Lactamase 2 (VIM-2) Inhibitor.

Authors:  Yang Xiang; Yue-Juan Zhang; Ying Ge; Yajun Zhou; Cheng Chen; Weixiao Yuan Wahlgren; Xiangshi Tan; Xi Chen; Ke-Wu Yang
Journal:  Biomolecules       Date:  2020-01-01

9.  Mercaptoacetate thioesters and their hydrolysate mercaptoacetic acids jointly inhibit metallo-β-lactamase L1.

Authors:  Cheng Chen; Yang Xiang; Ya Liu; Xiangdong Hu; Ke-Wu Yang
Journal:  Medchemcomm       Date:  2018-05-17       Impact factor: 3.597

10.  Inhibition of New Delhi Metallo-β-Lactamase 1 (NDM-1) Producing Escherichia coli IR-6 by Selected Plant Extracts and Their Synergistic Actions with Antibiotics.

Authors:  Brinda Chandar; Sundar Poovitha; Kaliappan Ilango; Ramasamy MohanKumar; Madasamy Parani
Journal:  Front Microbiol       Date:  2017-08-22       Impact factor: 5.640
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