OBJECTIVES: Increases in case numbers for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) have been noted on a global level. This study analysed 13 years of testing data to better understand case detection trends over time. METHODS: Data consisted of all nucleic acid probe and nucleic acid amplification diagnostic testing for CT and NG for the population of Manitoba, Canada (1.2 million); January 2000 to December 2012. Logistic regression models were used to analyse ORs associated with positive CT and NG tests by year. Included in the model as predictor variables were test type, specimen type, patient age and residence location. RESULTS: For both male and female CT results, unadjusted OR by year mimicked absolute case counts, reflecting a general increase over time in case counts. Adjustment for laboratory-related variables altered this relationship such that a general decline in the odds of identifying a CT case over time was evident. For both male and female NG results, adjustment for laboratory and demographic variables altered the OR associated with each year, but to a lesser extent than for CT. CONCLUSIONS: Temporal trends associated with CT case numbers should be interpreted after controlling, at a minimum, for the influence of laboratory-related variables. Interpretation of NG trends is feasible using only the number of reported NG cases. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
OBJECTIVES: Increases in case numbers for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) have been noted on a global level. This study analysed 13 years of testing data to better understand case detection trends over time. METHODS: Data consisted of all nucleic acid probe and nucleic acid amplification diagnostic testing for CT and NG for the population of Manitoba, Canada (1.2 million); January 2000 to December 2012. Logistic regression models were used to analyse ORs associated with positive CT and NG tests by year. Included in the model as predictor variables were test type, specimen type, patient age and residence location. RESULTS: For both male and female CT results, unadjusted OR by year mimicked absolute case counts, reflecting a general increase over time in case counts. Adjustment for laboratory-related variables altered this relationship such that a general decline in the odds of identifying a CT case over time was evident. For both male and female NG results, adjustment for laboratory and demographic variables altered the OR associated with each year, but to a lesser extent than for CT. CONCLUSIONS: Temporal trends associated with CT case numbers should be interpreted after controlling, at a minimum, for the influence of laboratory-related variables. Interpretation of NG trends is feasible using only the number of reported NG cases. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
Entities:
Keywords:
CHLAMYDIA TRACHOMATIS; DNA AMPLIFICATION; DNA PROBE; NEISSERIA GONORRHOEA; PUBLIC HEALTH
Authors: Laura H Thompson; Zoann Nugent; John L Wylie; Carla Loeppky; Paul Van Caeseele; James F Blanchard; Nancy Yu Journal: Microbiol Insights Date: 2019-02-27