Literature DB >> 25968633

Targeting L-type amino acid transporter 1 for anticancer therapy: clinical impact from diagnostics to therapeutics.

Su-Eon Jin1, Hyo-Eon Jin2, Soon-Sun Hong3.   

Abstract

INTRODUCTION: L-type amino acid transporter 1 (LAT1) is one of the amino acid transporters. It is overexpressed in various types of cancer cells, while it is produced restrictedly in normal tissues. AREAS COVERED: We discuss its characteristics in cancer cells compared with normal cells. We also mention the current applications to target LAT1 for anticancer therapy focusing on prognostic biomarkers, radio-labeled tumor imaging reagents, amino acid-stapled prodrugs, LAT1-mediated enhanced transport of anticancer drugs and LAT1 inhibitors. EXPERT OPINION: LAT1 can be a versatile target to promisingly develop transporter-based drugs with enhanced drug delivery potential for anticancer therapy.

Entities:  

Keywords:  L-type amino acid transporter 1; anticancer drug; cancer; inhibitor; prodrug; prognostic biomarker; tumor imaging

Mesh：

Substances：

Year:  2015        PMID： 25968633     DOI： 10.1517/14728222.2015.1044975

Source DB:  PubMed          Journal:  Expert Opin Ther Targets        ISSN： 1472-8222            Impact factor:   6.902


  11 in total

1.  Carriership of the rs113883650/rs2287120 haplotype of the SLC7A5 (LAT1) gene increases the risk of obesity in infants with phenylketonuria.

Authors:  Miroslaw Bik-Multanowski; Anna Madetko-Talowska; Iwona Betka; Elzbieta Swieczka; Bozena Didycz; Karolina Orchel-Szastak; Kinga Bik-Multanowska; Ewa Starostecka; Joanna Jaglowska; Renata Mozrzymas; Joanna Zolkowska; Katarzyna Chyz; Dorota Korycinska-Chaaban
Journal:  Mol Genet Metab Rep       Date:  2020-08-21

2.  Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).

Authors:  Huan-Chieh Chien; Claire Colas; Karissa Finke; Seth Springer; Laura Stoner; Arik A Zur; Brooklynn Venteicher; Jerome Campbell; Colton Hall; Andrew Flint; Evan Augustyn; Christopher Hernandez; Nathan Heeren; Logan Hansen; Abby Anthony; Justine Bauer; Dimitrios Fotiadis; Avner Schlessinger; Kathleen M Giacomini; Allen A Thomas
Journal:  J Med Chem       Date:  2018-08-10       Impact factor: 7.446

3.  Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses.

Authors:  Bo Ruem Yoon; Yoon-Jeong Oh; Seong Wook Kang; Eun Bong Lee; Won-Woo Lee
Journal:  Front Immunol       Date:  2018-01-25       Impact factor: 7.561

4.  JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells.

Authors:  Dae Woo Choi; Do Kyung Kim; Yoshikatsu Kanai; Michael F Wempe; Hitoshi Endou; Jong-Keun Kim
Journal:  Korean J Physiol Pharmacol       Date:  2017-10-30       Impact factor: 2.016

5.  Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis.

Authors:  Magdalena Markowicz-Piasecka; Johanna Huttunen; Ahmed Montaser; Kristiina M Huttunen
Journal:  Apoptosis       Date:  2020-06       Impact factor: 4.677

6.  Synthesis of Gemcitabine-Threonine Amide Prodrug Effective on Pancreatic Cancer Cells with Improved Pharmacokinetic Properties.

Authors:  Sungwoo Hong; Zhenghuan Fang; Hoi-Yun Jung; Jin-Ha Yoon; Soon-Sun Hong; Han-Joo Maeng
Journal:  Molecules       Date:  2018-10-11       Impact factor: 4.411

7.  A side-by-side evaluation of [18F]FDOPA enantiomers for non-invasive detection of neuroendocrine tumors by positron emission tomography.

Authors:  Athira Narayan; Yu Yan; Ala Lisok; Mary Brummet; Martin G Pomper; Wojciech G Lesniak; Robert F Dannals; Vanessa F Merino; Babak Behnam Azad
Journal:  Oncotarget       Date:  2019-10-08

Review 8.  L-Type amino acid transporter 1 as a target for drug delivery.

Authors:  Elena Puris; Mikko Gynther; Seppo Auriola; Kristiina M Huttunen
Journal:  Pharm Res       Date:  2020-05-06       Impact factor: 4.200

9.  Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids.

Authors:  Shuhua Li; Wen Su; Hao Wu; Ting Yuan; Chang Yuan; Jun Liu; Gang Deng; Xingchun Gao; Zeming Chen; Youmei Bao; Fanglong Yuan; Shixin Zhou; Hongwei Tan; Yunchao Li; Xiaohong Li; Louzhen Fan; Jia Zhu; Ann T Chen; Fuyao Liu; Yu Zhou; Miao Li; Xingchen Zhai; Jiangbing Zhou
Journal:  Nat Biomed Eng       Date:  2020-03-30       Impact factor: 25.671

10.  Tumor-Targeted Fluorescence Imaging and Mechanisms of Tumor Cell-Derived Carbon Nanodots.

Authors:  Taotao Huo; Wenshuai Li; Dong Liang; Rongqin Huang
Journal:  Pharmaceutics       Date:  2022-01-14       Impact factor: 6.321
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