María Torres-Durán1, Alberto Ruano-Ravina2,3, Isaura Parente-Lamelas4, Virginia Leiro-Fernández1, José Abal-Arca4, Carmen Montero-Martínez5, Carolina Pena-Álvarez6, Olalla Castro-Añón7, Antonio Golpe-Gómez8, Cristina Martínez9, Rosirys Guzmán-Taveras9, María José Mejuto-Martí10, Mariano Provencio11, Alberto Fernández-Villar1, Juan Miguel Barros-Dios2,3,12. 1. a Service of Neumology, University Hospital Complex of Vigo , Spain. 2. b Department of Preventive Medicine and Public Health , University of Santiago de Compostela , Spain. 3. c CIBER de Epidemiología y Salud Pública, CIBERESP , Spain. 4. d Service of Neumology, Ourense Hospital Complex , Spain. 5. e Service of Neumology, University Hospital Complex of A Coruña , Spain. 6. f Service of Oncology, Pontevedra Hospital Complex, Pontevedra , Spain. 7. h Service of Neumology, Hospital Lucus Augusti , Spain. 8. g Service of Neumology, Santiago de Compostela University Clinic Hospital , Spain. 9. i National Institute of Silicosis, University Hospital of Asturias , Oviedo , Spain. 10. j Service of Neumology, Hospital Arquitecto Marcide , Ferrol , Spain. 11. k Service of Oncology, Hospital Puerta de Hierro , Madrid , Spain. 12. l Service of Preventive Medicine, University Hospital Complex of Santiago de Compostela , Spain.
Abstract
PURPOSE: The aim of this study is to assess if there is a relationship between residential radon and lung cancer histological types and patients' age at diagnosis. MATERIALS AND METHODS: We conducted a multicenter hospital-based case-control study with eight participating hospitals. We included 216 never-smoking cases with primary lung cancer and 329 never-smoking controls. Controls were frequency matched with cases on age and sex distribution. Of them, 198 cases (91.7%) and 275 controls (83.5%) had residential radon measurements. RESULTS: Lung cancer risk reached statistical significance only for adenocarcinoma (Odds ratio [OR] 2.19; 95% Confidence interval [CI] 1.44-3.33), for other histologies the results were marginally significant. Residential radon level was higher for patients diagnosed before 50 and 60 years old than for older lung cancer cases. CONCLUSIONS: Residential radon in never smokers seems to be a risk factor for all lung cancer histologies. Individuals diagnosed at a younger age have a higher residential radon concentration, suggesting an accumulative effect on lung cancer appearance.
PURPOSE: The aim of this study is to assess if there is a relationship between residential radon and lung cancer histological types and patients' age at diagnosis. MATERIALS AND METHODS: We conducted a multicenter hospital-based case-control study with eight participating hospitals. We included 216 never-smoking cases with primary lung cancer and 329 never-smoking controls. Controls were frequency matched with cases on age and sex distribution. Of them, 198 cases (91.7%) and 275 controls (83.5%) had residential radon measurements. RESULTS:Lung cancer risk reached statistical significance only for adenocarcinoma (Odds ratio [OR] 2.19; 95% Confidence interval [CI] 1.44-3.33), for other histologies the results were marginally significant. Residential radon level was higher for patients diagnosed before 50 and 60 years old than for older lung cancer cases. CONCLUSIONS: Residential radon in never smokers seems to be a risk factor for all lung cancer histologies. Individuals diagnosed at a younger age have a higher residential radon concentration, suggesting an accumulative effect on lung cancer appearance.
Authors: Rayjean J Hung; Margaret R Spitz; Richard S Houlston; Ann G Schwartz; John K Field; Jun Ying; Yafang Li; Younghun Han; Xuemei Ji; Wei Chen; Xifeng Wu; Ivan P Gorlov; Jie Na; Mariza de Andrade; Geoffrey Liu; Yonathan Brhane; Nancy Diao; Angela Wenzlaff; Michael P A Davies; Triantafillos Liloglou; Maria Timofeeva; Thomas Muley; Hedy Rennert; Walid Saliba; Bríd M Ryan; Elise Bowman; Juan-Miguel Barros-Dios; Mónica Pérez-Ríos; Hal Morgenstern; Shanbeh Zienolddiny; Vidar Skaug; Donatella Ugolini; Stefano Bonassi; Erik H F M van der Heijden; Adonina Tardon; Stig E Bojesen; Maria Teresa Landi; Mattias Johansson; Heike Bickeböller; Susanne Arnold; Loic Le Marchand; Olle Melander; Angeline Andrew; Kjell Grankvist; Neil Caporaso; M Dawn Teare; Matthew B Schabath; Melinda C Aldrich; Lambertus A Kiemeney; H-Erich Wichmann; Philip Lazarus; Jose Mayordomo; Monica Neri; Aage Haugen; Zuo-Feng Zhang; Alberto Ruano-Raviña; Hermann Brenner; Curtis C Harris; Irene Orlow; Gadi Rennert; Angela Risch; Paul Brennan; David C Christiani; Christopher I Amos; Ping Yang; Olga Y Gorlova Journal: J Thorac Oncol Date: 2019-04-19 Impact factor: 15.609
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