Amanda L Sherman1, Matthew C Morris2, Stephen Bruehl3, Travis D Westbrook4, Lynn S Walker5,6. 1. Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA. 2. Department of Family and Community Medicine, Meharry Medical College, Nashville, TN, USA. 3. Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA. 4. Department of Psychology, The Ohio State University, Columbus, OH, USA. 5. Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA. lynn.walker@vanderbilt.edu. 6. Division of Adolescent and Young Adult Health, Monroe Carell Jr. Children's Hospital at Vanderbilt, 2146 Belcourt Ave., Nashville, TN, 37212, USA. lynn.walker@vanderbilt.edu.
Abstract
BACKGROUND: Individuals with functional gastrointestinal disorders (FGIDs) report experiencing trauma more often than healthy controls, but little is known regarding psychophysical correlates. PURPOSE: The purpose of this study was to test the hypothesis that adolescents and young adults with FGIDs since childhood and a trauma history (n = 38) would exhibit heightened temporal summation to thermal pain stimuli, an index of central sensitization, and greater clinical symptoms compared to patients with FGIDs and no trauma history (n = 95) and healthy controls (n = 135). METHODS: Participants completed self-report measures, an experimental pain protocol, and psychiatric diagnostic interview as part of a larger longitudinal study. RESULTS: FGID + Trauma patients exhibited greater temporal summation than FGID + No Trauma patients and healthy controls. Additionally, FGID + Trauma patients exhibited greater gastrointestinal and non-gastrointestinal symptom severity, number of chronic pain sites, and disability. CONCLUSIONS: Assessing for trauma history in patients with FGIDs could identify a subset at risk for greater central sensitization and pain-related symptoms.
BACKGROUND: Individuals with functional gastrointestinal disorders (FGIDs) report experiencing trauma more often than healthy controls, but little is known regarding psychophysical correlates. PURPOSE: The purpose of this study was to test the hypothesis that adolescents and young adults with FGIDs since childhood and a trauma history (n = 38) would exhibit heightened temporal summation to thermal pain stimuli, an index of central sensitization, and greater clinical symptoms compared to patients with FGIDs and no trauma history (n = 95) and healthy controls (n = 135). METHODS:Participants completed self-report measures, an experimental pain protocol, and psychiatric diagnostic interview as part of a larger longitudinal study. RESULTS: FGID + Traumapatients exhibited greater temporal summation than FGID + No Traumapatients and healthy controls. Additionally, FGID + Traumapatients exhibited greater gastrointestinal and non-gastrointestinal symptom severity, number of chronic pain sites, and disability. CONCLUSIONS: Assessing for trauma history in patients with FGIDs could identify a subset at risk for greater central sensitization and pain-related symptoms.
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