BACKGROUND AND AIM: Although the influence of cigarette smoking on the incident risk of liver cancer has been determined, the association between smoking and liver cancer mortality remains uncertain. METHODS: We searched Pubmed, EmBase, and Web of Science databases to obtain eligible studies. Hazard ratio (HR) value and 95% confidential intervals (CI) were pooled by using a random-effects model, and dose-response analyses were conducted to quantify associations between smoking and mortality from liver cancer. RESULTS: A total of 27 articles involving four million participants from seven countries by retrieval (published 1986-2014) were finally included. Pooled HR values for liver cancer mortality was 1.45 (95% CI: 1.33-1.59), 1.22 (95% CI: 1.11-1.34) and 1.16 (95% CI: 1.01-1.32) for current, former, and ever smokers, respectively, when compared with nonsmokers. The risk increased by 7.1% (95% CI: 1.4-13.2) for per additional 10 cigarettes per day and by 5.2% (95% CI: 0.02-11.2) for per additional 10 pack-years. In our population recruiting 597 patients with liver cancer, smoking status was further identified as a significant determinant factor of tumor size and serum level of gamma-glutamyl transpeptidase, but not a significant prognostic factor. CONCLUSIONS: Cigarette smoking, especially current smoking, significantly increased mortality risk from liver cancer.
BACKGROUND AND AIM: Although the influence of cigarette smoking on the incident risk of liver cancer has been determined, the association between smoking and liver cancer mortality remains uncertain. METHODS: We searched Pubmed, EmBase, and Web of Science databases to obtain eligible studies. Hazard ratio (HR) value and 95% confidential intervals (CI) were pooled by using a random-effects model, and dose-response analyses were conducted to quantify associations between smoking and mortality from liver cancer. RESULTS: A total of 27 articles involving four million participants from seven countries by retrieval (published 1986-2014) were finally included. Pooled HR values for liver cancer mortality was 1.45 (95% CI: 1.33-1.59), 1.22 (95% CI: 1.11-1.34) and 1.16 (95% CI: 1.01-1.32) for current, former, and ever smokers, respectively, when compared with nonsmokers. The risk increased by 7.1% (95% CI: 1.4-13.2) for per additional 10 cigarettes per day and by 5.2% (95% CI: 0.02-11.2) for per additional 10 pack-years. In our population recruiting 597 patients with liver cancer, smoking status was further identified as a significant determinant factor of tumor size and serum level of gamma-glutamyl transpeptidase, but not a significant prognostic factor. CONCLUSIONS: Cigarette smoking, especially current smoking, significantly increased mortality risk from liver cancer.
Authors: Nicole M Niehoff; Emily C Zabor; Jaya Satagopan; Anders Widell; Thomas R O'Brien; Mingdong Zhang; Nathaniel Rothman; Tom K Grimsrud; Stephen K Van Den Eeden; Lawrence S Engel Journal: Environ Res Date: 2020-05-20 Impact factor: 6.498
Authors: Lenore D Pitstick; Joanna Goral; Ryan A Schmelter; Christine M Fuja; Mae J Ciancio; Matthew Pytynia; Alice Meyer; Jacalyn M Green Journal: PLoS One Date: 2022-05-31 Impact factor: 3.752
Authors: Cao Maomao; Li He; Sun Dianqin; He Siyi; Yan Xinxin; Yang Fan; Zhang Shaoli; Xia Changfa; Lei Lin; Peng Ji; Chen Wanqing Journal: Cancer Biol Med Date: 2022-08-30 Impact factor: 5.347