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Literature DB >> 25967266

Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse.

J F Oliveira da Cruz¹, L M Robin², F Drago³, G Marsicano⁴, M Metna-Laurent⁵.

Abstract

The endocannabinoid system is an important regulator of physiological functions. In the brain, this control is mainly exerted through the type-1-cannabinoid (CB1) receptors. CB1 receptors are abundant at neuron terminals where their stimulation inhibits neurotransmitter release. However, CB1 receptors are also expressed in astrocytes and recent studies showed that astroglial cannabinoid signaling is a key element of the tripartite synapse. In this review we discuss the different mechanisms by which astroglial CB1 receptors control synaptic transmission and plasticity. The recent involvement of astroglial CB1 receptors in the effects of cannabinoids on memory highlights their key roles in cognitive processes and further indicates that astrocytes are central active elements of high-order brain functions.

Entities: Chemical Gene

Keywords: astroglial cells; cannabinoid receptors; synaptic plasticity; tripartite synapse; working memory

Mesh：

Substances：

Year: 2015 PMID： 25967266 DOI： 10.1016/j.neuroscience.2015.05.002

Source DB: PubMed Journal: Neuroscience ISSN： 0306-4522 Impact factor: 3.590

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Cited

29 in total

1. Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex.

Authors: D Scheggia; E Zamberletti; N Realini; M Mereu; G Contarini; V Ferretti; F Managò; G Margiani; R Brunoro; T Rubino; M A De Luca; D Piomelli; D Parolaro; F Papaleo
Journal: Mol Psychiatry Date: 2017-06-20 Impact factor: 15.992

2. Astrocytic Mechanisms Involving Kynurenic Acid Control Δ⁹-Tetrahydrocannabinol-Induced Increases in Glutamate Release in Brain Reward-Processing Areas.

Authors: Maria E Secci; Paola Mascia; Claudia Sagheddu; Sarah Beggiato; Miriam Melis; Andrea C Borelli; Maria C Tomasini; Leigh V Panlilio; Charles W Schindler; Gianluigi Tanda; Sergi Ferré; Charles W Bradberry; Luca Ferraro; Marco Pistis; Steven R Goldberg; Robert Schwarcz; Zuzana Justinova
Journal: Mol Neurobiol Date: 2018-08-27 Impact factor: 5.590

Review 3. Druggable targets of the endocannabinoid system: Implications for the treatment of HIV-associated neurocognitive disorder.

Authors: Mariah M Wu; Xinwen Zhang; Melissa J Asher; Stanley A Thayer
Journal: Brain Res Date: 2019-09-17 Impact factor: 3.252

Review 9. The intersection of astrocytes and the endocannabinoid system in the lateral habenula: on the fast-track to novel rapid-acting antidepressants.

Authors: Shokouh Arjmand; Anne M Landau; Bardia Varastehmoradi; Roberto Andreatini; Sâmia Joca; Gregers Wegener
Journal: Mol Psychiatry Date: 2022-05-18 Impact factor: 15.992

Review 10. Potential of Cannabinoid Receptor Ligands as Treatment for Substance Use Disorders.

Authors: Ewa Galaj; Zheng-Xiong Xi
Journal: CNS Drugs Date: 2019-10 Impact factor: 5.749

Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse.

1. Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex.

2. Astrocytic Mechanisms Involving Kynurenic Acid Control Δ⁹-Tetrahydrocannabinol-Induced Increases in Glutamate Release in Brain Reward-Processing Areas.

Review 3. Druggable targets of the endocannabinoid system: Implications for the treatment of HIV-associated neurocognitive disorder.

Review 4. Cannabis use during pregnancy: Pharmacokinetics and effects on child development.

Review 5. CB₁ and CB₂ Receptor Pharmacology.

Review 6. Cannabinoids and glial cells: possible mechanism to understand schizophrenia.

7. Insulin Modulates Excitatory Synaptic Transmission and Synaptic Plasticity in the Mouse Hippocampus.

8. Ultrastructural localization of cannabinoid CB1 and mGluR5 receptors in the prefrontal cortex and amygdala.

Review 9. The intersection of astrocytes and the endocannabinoid system in the lateral habenula: on the fast-track to novel rapid-acting antidepressants.

Review 10. Potential of Cannabinoid Receptor Ligands as Treatment for Substance Use Disorders.

Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse.

1. Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex.

2. Astrocytic Mechanisms Involving Kynurenic Acid Control Δ9-Tetrahydrocannabinol-Induced Increases in Glutamate Release in Brain Reward-Processing Areas.

Review 3. Druggable targets of the endocannabinoid system: Implications for the treatment of HIV-associated neurocognitive disorder.

Review 4. Cannabis use during pregnancy: Pharmacokinetics and effects on child development.

Review 5. CB1 and CB2 Receptor Pharmacology.

Review 6. Cannabinoids and glial cells: possible mechanism to understand schizophrenia.

7. Insulin Modulates Excitatory Synaptic Transmission and Synaptic Plasticity in the Mouse Hippocampus.

8. Ultrastructural localization of cannabinoid CB1 and mGluR5 receptors in the prefrontal cortex and amygdala.

Review 9. The intersection of astrocytes and the endocannabinoid system in the lateral habenula: on the fast-track to novel rapid-acting antidepressants.

Review 10. Potential of Cannabinoid Receptor Ligands as Treatment for Substance Use Disorders.

2. Astrocytic Mechanisms Involving Kynurenic Acid Control Δ⁹-Tetrahydrocannabinol-Induced Increases in Glutamate Release in Brain Reward-Processing Areas.

Review 5. CB₁ and CB₂ Receptor Pharmacology.