| Literature DB >> 25967062 |
Emil F Khisamutdinov1, My Nguyen Hoan Bui, Daniel Jasinski, Zhengyi Zhao, Zheng Cui, Peixuan Guo.
Abstract
Precise shape control of architectures at the nanometer scale is an intriguing but extremely challenging facet. RNA has recently emerged as a unique material and thermostable building block for use in nanoparticle construction. Here, we describe a simple method from design to synthesis of RNA triangle, square, and pentagon by stretching RNA 3WJ native angle from 60° to 90° and 108°, using the three-way junction (3WJ) of the pRNA from bacteriophage phi29 dsDNA packaging motor. These methods for the construction of elegant polygons can be applied to other RNA building blocks including the utilization and application of RNA 4-way, 5-way, and other multi-way junctions.Entities:
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Year: 2015 PMID： 25967062 DOI： 10.1007/978-1-4939-2730-2_15
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745