Yi Xiong Gao1, Hong Xia Zhang2, Jing Guang Li3, Lei Zhang3, Xin Wei Yu4, Jia Lu He4, Xiao Hong Shang3, Yun Feng Zhao3, Yong Ning Wu3. 1. China National Center for Food Safety Risk Assessment, Key Lab of Food Safety Risk Assessment, Ministry of Health, Beijing 100021, China; National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. 2. China National Center for Food Safety Risk Assessment, Key Lab of Food Safety Risk Assessment, Ministry of Health, Beijing 100021, China; Maternal and Child Care Service Centre of Shiquan County, Ankang 725200, Shaanxi, China. 3. China National Center for Food Safety Risk Assessment, Key Lab of Food Safety Risk Assessment, Ministry of Health, Beijing 100021, China. 4. Zhejiang Provincial Key Laboratory of Health Risk Factors for Seafood, Zhoushan Municipal Center of Disease Control and Prevention, Zhoushan 316021, Zhejiang, China.
Abstract
OBJECTIVE: To assess the net health effect caused by the consumption of specific marine species based on Benefit-Risk Analysis for Foods (BRAFO)-tiered approach. METHODS: Twenty species were collected from the Zhoushan Archipelago, China. Concentrations of n-3 long-chain polyunsaturated fatty acids, methyl mercury (MeHg), and dioxin-like compounds (DLCs) in the samples were analyzed for benefit risk assessment based on BRAFO-tiered approach. RESULTS: Based on the BRAFO-tiered approach, reference scenario (no intake) and alternative scenario (intake of specific species of 200 g/week) were determined. The exposure to MeHg/DLCs via alternative scenario of all studied species did not exceed provisional tolerable weekly/monthly intake. However, the adult population with high DLCs exposure in China would significantly exceed the upper limit of DLCs via an additional alternative scenario of some species such as Auxis thazard. The results of deterministic computation showed that alternative scenario of all studied species generated clear net beneficial effects on death prevention and child IQ gain. CONCLUSION: The alternative scenario of all studied species could be recommended to population with average DLCs exposure, and the reference scenario of species with relatively high DLCs concentration could be recommended to population exposed to high DLCs.
OBJECTIVE: To assess the net health effect caused by the consumption of specific marine species based on Benefit-Risk Analysis for Foods (BRAFO)-tiered approach. METHODS: Twenty species were collected from the Zhoushan Archipelago, China. Concentrations of n-3 long-chain polyunsaturated fatty acids, methyl mercury (MeHg), and dioxin-like compounds (DLCs) in the samples were analyzed for benefit risk assessment based on BRAFO-tiered approach. RESULTS: Based on the BRAFO-tiered approach, reference scenario (no intake) and alternative scenario (intake of specific species of 200 g/week) were determined. The exposure to MeHg/DLCs via alternative scenario of all studied species did not exceed provisional tolerable weekly/monthly intake. However, the adult population with high DLCs exposure in China would significantly exceed the upper limit of DLCs via an additional alternative scenario of some species such as Auxis thazard. The results of deterministic computation showed that alternative scenario of all studied species generated clear net beneficial effects on death prevention and child IQ gain. CONCLUSION: The alternative scenario of all studied species could be recommended to population with average DLCs exposure, and the reference scenario of species with relatively high DLCs concentration could be recommended to population exposed to high DLCs.