Literature DB >> 25966689

Emerging Alternative Functions for the Auxiliary Subunits of the Voltage-Gated Calcium Channels.

Franz Hofmann1, Anouar Belkacemi, Veit Flockerzi.   

Abstract

Voltage gated calcium channels (Cav) are composed of up to five proteins: The ion conducting pore subunit α1 and the auxiliary subunits α2, δ, β, and γ. Recent reports show that Cavα1 and Cavβ comprise the calcium channel core complex and that β, α2 δ and γ may serve additional roles that are independent of the Cavα1 subunit. This short review will summarize these emerging functions.

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Year:  2015        PMID: 25966689     DOI: 10.2174/1874467208666150507110202

Source DB:  PubMed          Journal:  Curr Mol Pharmacol        ISSN: 1874-4672            Impact factor:   3.339


  6 in total

1.  High-Resolution Structures of K+ Channels.

Authors:  Qiu-Xing Jiang
Journal:  Handb Exp Pharmacol       Date:  2021

Review 2.  Voltage-Gated Ca2+-Channel α1-Subunit de novo Missense Mutations: Gain or Loss of Function - Implications for Potential Therapies.

Authors:  Jörg Striessnig
Journal:  Front Synaptic Neurosci       Date:  2021-03-03

3.  The β2-Subunit of Voltage-Gated Calcium Channels Regulates Cardiomyocyte Hypertrophy.

Authors:  Simone Pickel; Yiliam Cruz-Garcia; Sandra Bandleon; Katalin Barkovits; Cornelia Heindl; Katharina Völker; Marco Abeßer; Kathy Pfeiffer; Alice Schaaf; Katrin Marcus; Petra Eder-Negrin; Michaela Kuhn; Erick Miranda-Laferte
Journal:  Front Cardiovasc Med       Date:  2021-07-07

4.  Prolonged AT1R activation induces CaV1.2 channel internalization in rat cardiomyocytes.

Authors:  Tamara Hermosilla; Matías Encina; Danna Morales; Cristian Moreno; Carolina Conejeros; Hilda M Alfaro-Valdés; Felipe Lagos-Meza; Felipe Simon; Christophe Altier; Diego Varela
Journal:  Sci Rep       Date:  2017-08-31       Impact factor: 4.379

5.  Nanoenviroments of the β-Subunit of L-Type Voltage-Gated Calcium Channels in Adult Cardiomyocytes.

Authors:  Yiliam Cruz-Garcia; Katalin Barkovits; Michael Kohlhaas; Simone Pickel; Michelle Gulentz; Cornelia Heindl; Kathy Pfeiffer; Petra Eder-Negrin; Christoph Maack; Katrin Marcus; Michaela Kuhn; Erick Miranda-Laferte
Journal:  Front Cell Dev Biol       Date:  2022-01-03

Review 6.  CaV channels and cancer: canonical functions indicate benefits of repurposed drugs as cancer therapeutics.

Authors:  Paul J Buchanan; Karen D McCloskey
Journal:  Eur Biophys J       Date:  2016-06-24       Impact factor: 1.733

  6 in total

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