Elena Libhaber1, Karen Sliwa1, Katrin Bachelier2, Kim Lamont1, Michael Böhm3. 1. Soweto Cardiovascular Research Unit, University of the Witwatersrand, South Africa. 2. Universitätsklinikum des Saarlandes, Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Str. 1, D 66424 Homburg, Saar, Germany. 3. Universitätsklinikum des Saarlandes, Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Str. 1, D 66424 Homburg, Saar, Germany. Electronic address: michael.boehm@uks.eu.
Abstract
BACKGROUND: Patients with peripartum cardiomyopathy (PPCM) present with low blood pressure (SBP) often preventing uptitration of heart failure medication. We aimed to study prediction of risk and the contribution of high resting heart rate (HR) and low SBP to risk in recent onset of PPCM. METHODS: Clinical assessment with HR and SBP, echocardiography and laboratory results were obtained at baseline and at six months on 206 patients with recent onset PPCM enrolled at two tertiary care centers in South Africa. Poor outcome was defined as the combined endpoint of death, LVEF<35% or remaining in New York Heart Association (NYHA) functional class III/IV at six months. Complete LV recovery was defined as LVEF ≥ 55% at six months. RESULTS: Poor outcome was observed in 110 of 220 patients (53%), with 26 patients dying at six months (12.6%). There were 98 (47.5%) patients with SBP ≤ 110 mmHg. Patients with high HR (HR ≥ 100) and low SBP (< 110 mmHg) tended to have worse outcomes than patients below the HR median and high SBP. PPCM patients with low SBP and high HR were less likely to be on ACE-inhibitors (n = 35, 69% versus n = 129, 84%, p = 0.024) and on the beta blocker carvedilol (n = 24, 47% versus n = 98, 64%, p = 0.047). Low SBP, high HR and left ventricular end diastolic diameter at baseline were predictors of poor outcome. Patients with low SBP and high HR had the highest mortality (p = 0.0023). CONCLUSIONS: These findings suggest increased risk in patients with PPCM presenting with low SBP and high HR on standard heart failure medication possibly having implications on HF management.
BACKGROUND:Patients with peripartum cardiomyopathy (PPCM) present with low blood pressure (SBP) often preventing uptitration of heart failure medication. We aimed to study prediction of risk and the contribution of high resting heart rate (HR) and low SBP to risk in recent onset of PPCM. METHODS: Clinical assessment with HR and SBP, echocardiography and laboratory results were obtained at baseline and at six months on 206 patients with recent onset PPCM enrolled at two tertiary care centers in South Africa. Poor outcome was defined as the combined endpoint of death, LVEF<35% or remaining in New York Heart Association (NYHA) functional class III/IV at six months. Complete LV recovery was defined as LVEF ≥ 55% at six months. RESULTS: Poor outcome was observed in 110 of 220 patients (53%), with 26 patients dying at six months (12.6%). There were 98 (47.5%) patients with SBP ≤ 110 mmHg. Patients with high HR (HR ≥ 100) and low SBP (< 110 mmHg) tended to have worse outcomes than patients below the HR median and high SBP. PPCM patients with low SBP and high HR were less likely to be on ACE-inhibitors (n = 35, 69% versus n = 129, 84%, p = 0.024) and on the beta blocker carvedilol (n = 24, 47% versus n = 98, 64%, p = 0.047). Low SBP, high HR and left ventricular end diastolic diameter at baseline were predictors of poor outcome. Patients with low SBP and high HR had the highest mortality (p = 0.0023). CONCLUSIONS: These findings suggest increased risk in patients with PPCM presenting with low SBP and high HR on standard heart failure medication possibly having implications on HF management.
Authors: Karen Sliwa; Mark C Petrie; Peter van der Meer; Alexandre Mebazaa; Denise Hilfiker-Kleiner; Alice M Jackson; Aldo P Maggioni; Cecile Laroche; Vera Regitz-Zagrosek; Maria Schaufelberger; Luigi Tavazzi; Jolien W Roos-Hesselink; Petar Seferovic; Karin van Spaendonck-Zwarts; Amam Mbakwem; Michael Böhm; Frederic Mouquet; Burkert Pieske; Mark R Johnson; Righab Hamdan; Piotr Ponikowski; Dirk J Van Veldhuisen; John J V McMurray; Johann Bauersachs Journal: Eur Heart J Date: 2020-10-14 Impact factor: 29.983
Authors: Juliet Nabbaale; Emmy Okello; Davis Kibirige; Isaac Ssekitoleko; Joseph Isanga; Patience Karungi; Elias Sebatta; Zhang Wan Zhu; Annettee Nakimuli; John Omagino; James Kayima Journal: PLoS One Date: 2020-10-21 Impact factor: 3.240
Authors: Anudeep K Dodeja; Francesca Siegel; Katherine Dodd; Marwan Ma'ayeh; Laxmi S Mehta; Margaret M Fuchs; Kara M Rood; May Ling Mah; Elisa A Bradley Journal: Open Heart Date: 2021-08