Anthony M Tolisano1, Christopher Klem1, Michael B Lustik2, Joseph C Sniezek3, J Blake Golden1. 1. Department of Otolaryngology, Tripler Army Medical Center, Honolulu, Hawaii. 2. Department of Clinical Investigations, Tripler Army Medical Center, Honolulu, Hawaii. 3. Division of Head and Neck Surgery, Swedish Cancer Institute, Seattle, Washington.
Abstract
BACKGROUND: The purpose of this study was to characterize the timing, histology, and behavior of second primary thyroid carcinoma (SPTC) developing after a diagnosis of head and neck squamous cell carcinoma (HNSCC). METHODS: We conducted a retrospective review of the Surveillance, Epidemiology, and End Results (SEER) 9 database. RESULTS: Patients with HNSCC who develop SPTC die 1.6 times sooner than those without SPTC. This effect is only seen if SPTC presents >6 months after diagnosis of HNSCC. Models were adjusted for age, sex, year of diagnosis, and location of HNSCC. There was no effect of prior radiation therapy on either mortality rates or time to development of thyroid cancer in patients with SPTC. The type of thyroid carcinoma that developed was similar between cohorts. CONCLUSION: The development of SPTC in patients with HNSCC results in decreased overall length of survival.
BACKGROUND: The purpose of this study was to characterize the timing, histology, and behavior of second primary thyroid carcinoma (SPTC) developing after a diagnosis of head and neck squamous cell carcinoma (HNSCC). METHODS: We conducted a retrospective review of the Surveillance, Epidemiology, and End Results (SEER) 9 database. RESULTS:Patients with HNSCC who develop SPTC die 1.6 times sooner than those without SPTC. This effect is only seen if SPTC presents >6 months after diagnosis of HNSCC. Models were adjusted for age, sex, year of diagnosis, and location of HNSCC. There was no effect of prior radiation therapy on either mortality rates or time to development of thyroid cancer in patients with SPTC. The type of thyroid carcinoma that developed was similar between cohorts. CONCLUSION: The development of SPTC in patients with HNSCC results in decreased overall length of survival.
Keywords:
Epidemiology; Surveillance; and End Results (SEER); head and neck squamous cell carcinoma; second primary malignancy; survival; thyroid cancer
Authors: Li Tao; Christina A Clarke; Aaron S Rosenberg; Ranjana H Advani; Brian A Jonas; Christopher R Flowers; Theresa H M Keegan Journal: Br J Haematol Date: 2017-05-25 Impact factor: 8.615