AIM: To analyze the outcome of patients with brain oligometastases treated by radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) after whole-brain radiotherapy (WBRT). PATIENTS AND METHODS: Overall survival (OS) and local control (LC) were evaluated in patients (patients) with 1-2 brain metastases. RESULTS: Forty-seven patients were selected. They were submitted to WBRT (median dose=3,750 cGy) followed by SRS (17 patients; median dose=1,500 cGy) or FSRT (30 patients; median dose=2,000 cGy). Median follow-up was 102 months (range=17-151); the median survival was 22 months for the SRS group and 16 months for the FSRT group. One-year and 5-year survival was 56% and 16%, respectively, in SRT and 62.1% and 3%, respectively, in FSRT. Neither treatment proved to significantly impact OS (p=0.4). The 1-year LC rates were 80% and 61.1% in the two groups, respectively (p=0.15). CONCLUSION: SRS or FSRT after WBRT could offer the same outcomes in patients with brain oligometasteses. Further investigation is warranted to confirm these data and define the optimal stereotactic modality. Copyright
AIM: To analyze the outcome of patients with brain oligometastases treated by radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) after whole-brain radiotherapy (WBRT). PATIENTS AND METHODS: Overall survival (OS) and local control (LC) were evaluated in patients (patients) with 1-2 brain metastases. RESULTS: Forty-seven patients were selected. They were submitted to WBRT (median dose=3,750 cGy) followed by SRS (17 patients; median dose=1,500 cGy) or FSRT (30 patients; median dose=2,000 cGy). Median follow-up was 102 months (range=17-151); the median survival was 22 months for the SRS group and 16 months for the FSRT group. One-year and 5-year survival was 56% and 16%, respectively, in SRT and 62.1% and 3%, respectively, in FSRT. Neither treatment proved to significantly impact OS (p=0.4). The 1-year LC rates were 80% and 61.1% in the two groups, respectively (p=0.15). CONCLUSION:SRS or FSRT after WBRT could offer the same outcomes in patients with brain oligometasteses. Further investigation is warranted to confirm these data and define the optimal stereotactic modality. Copyright
Authors: Valerio Nardone; Paolo Tini; Michelangelo Biondi; Lucio Sebaste; Eleonora Vanzi; Gianmarco De Otto; Giovanni Rubino; Tommaso Carfagno; Giuseppe Battaglia; Pierpaolo Pastina; Alfonso Cerase; Lorenzo Nicola Mazzoni; Fabrizio Banci Buonamici; Luigi Pirtoli Journal: Cureus Date: 2016-04-25