Yukihiro Yano1, Tomoyuki Otsuka2, Hiroshi Hirano3, Takeshi Uenami4, Akitoshi Satomi4, Muneyoshi Kuroyama4, Manabu Niinaka4, Tsutomu Yoneda4, Hiromi Kimura4, Masahide Mori4, Toshihiko Yamaguchi4, Soichiro Yokota4. 1. Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan yanoy@toneyama.go.jp. 2. Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate school of Medicine, Suita, Osaka, Japan. 3. Department of Laboratory Medicine, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan. 4. Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan.
Abstract
BACKGROUND/AIM: Little evidence exists regarding a relationship between survivin expression and prognosis in small cell lung cancer (SCLC). We investigated the relationship between survivin expression, clinical characteristics and prognosis in SCLC patients. MATERIALS AND METHODS: We retrospectively reviewed medical records of study patients and analyzed their tumor sections using nuclear survivin labeling index (LI). RESULTS: A significant correlation between nuclear survivin LI and clinical stage was found (p=0.012). In multivariate analysis, a significant association was found between survival and clinical stage (hazard ratio (HR)=2.09; 95 % confidence interval (CI)=1.08-4.31; p=0.027) but not between survival and nuclear survivin LI (HR=0.96; 95 % CI=0.91-1.02; p=0.2). CONCLUSION: We did not find any positive relationship between nuclear survivin expression and survival in SCLC patients. Conversely, we found a positive relationship between clinical stage and nuclear survivin LI, which is considered to be useful in deciding treatment strategies. Copyright
BACKGROUND/AIM: Little evidence exists regarding a relationship between survivin expression and prognosis in small cell lung cancer (SCLC). We investigated the relationship between survivin expression, clinical characteristics and prognosis in SCLCpatients. MATERIALS AND METHODS: We retrospectively reviewed medical records of study patients and analyzed their tumor sections using nuclear survivin labeling index (LI). RESULTS: A significant correlation between nuclear survivin LI and clinical stage was found (p=0.012). In multivariate analysis, a significant association was found between survival and clinical stage (hazard ratio (HR)=2.09; 95 % confidence interval (CI)=1.08-4.31; p=0.027) but not between survival and nuclear survivin LI (HR=0.96; 95 % CI=0.91-1.02; p=0.2). CONCLUSION: We did not find any positive relationship between nuclear survivin expression and survival in SCLCpatients. Conversely, we found a positive relationship between clinical stage and nuclear survivin LI, which is considered to be useful in deciding treatment strategies. Copyright