Dimple Chudasama1, Alexandra Rice1, Vladimir Anikin1, Gopal Soppa1, Paras Dalal2. 1. Departments of Thoracic Radiology and Thoracic Surgery, Harefield Hospital, The Royal Brompton and Harefield Hospital NHS Foundation Trust, Harefield, Middlesex, U.K. 2. Departments of Thoracic Radiology and Thoracic Surgery, Harefield Hospital, The Royal Brompton and Harefield Hospital NHS Foundation Trust, Harefield, Middlesex, U.K. p.dalal@rbht.nhs.uk.
Abstract
BACKGROUND/AIM: Radiofrequency ablation (RFA) is an increasingly utilised technique in patients with surgically-untreatable lesions. The effect of this therapy on circulating tumor cells (CTCs) is unknown. As far as we are aware of, this is the first study to evaluate the effects of RFA on CTCs in patients with malignant lung tumors immediately post-treatment. PATIENTS AND METHODS: Nine patients with primary or metastatic lung tumors underwent RFA therapy from June to November 2013. Blood samples were taken before and after RFA, and filtered through the ScreenCell CTC capture device. RESULTS: A general increase in CTCs in 7 out of the 9 cases was found, the largest increases were seen in the metastatic group. CONCLUSION: This study demonstrates that the manipulation and ablative procedure of lung tumors leads to immediate dissemination of tumor cells, the effects of which are unknown and require further investigation. Copyright
BACKGROUND/AIM: Radiofrequency ablation (RFA) is an increasingly utilised technique in patients with surgically-untreatable lesions. The effect of this therapy on circulating tumor cells (CTCs) is unknown. As far as we are aware of, this is the first study to evaluate the effects of RFA on CTCs in patients with malignant lung tumors immediately post-treatment. PATIENTS AND METHODS: Nine patients with primary or metastatic lung tumors underwent RFA therapy from June to November 2013. Blood samples were taken before and after RFA, and filtered through the ScreenCell CTC capture device. RESULTS: A general increase in CTCs in 7 out of the 9 cases was found, the largest increases were seen in the metastatic group. CONCLUSION: This study demonstrates that the manipulation and ablative procedure of lung tumors leads to immediate dissemination of tumor cells, the effects of which are unknown and require further investigation. Copyright
Authors: Malte Mohme; Sabine Riethdorf; Marc Dreimann; Stefan Werner; Cecile L Maire; Simon A Joosse; Frederic Bludau; Volkmar Mueller; Rui P L Neves; Nikolas H Stoecklein; Katrin Lamszus; Manfred Westphal; Klaus Pantel; Harriet Wikman; Sven O Eicker Journal: Sci Rep Date: 2017-08-03 Impact factor: 4.379