Fabio Cattaneo1, Germano Guerra2, Melania Parisi1, Angela Lucariello3, Antonio De Luca3, Nicolina De Rosa4, Gennaro Mazzarella4, Andrea Bianco5, Rosario Ammendola6. 1. Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, Naples, Italy. 2. Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy. 3. Section of Human Anatomy, Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Naples, Italy. 4. Department of Cardiothoracic and Respiratory Sciences, Monaldi Hospital, Second University of Naples, Naples, Italy. 5. Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy rosario.ammendola@unina.it andrea.bianco@unimol.it. 6. Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, Naples, Italy rosario.ammendola@unina.it andrea.bianco@unimol.it.
Abstract
BACKGROUND/AIM: Formyl-peptide receptors (FPRs) are expressed in several tissues and cell types. The identification of markers involved in cell growth may further allow for molecular profiling of lung cancer. We investigated the possible role of FPRs as molecular markers in several types of lung carcinomas which is the main cause of cancer death worldwide. MATERIALS AND METHODS: Tumor tissue samples were collected from six patients affected by lung cancer. Biopsies were analyzed for expression of FPR isoforms both in tumoral and peritumoral tissue by real-time polymerase chain reaction (PCR), western blot and immunofluorescence. RESULTS: Real-time PCR, western blot and immunofluorescence analyses showed that FPR expression is lower in types of human lung cancer tissues when compared to the surrounding peritumoral tissues. CONCLUSION: The study of the mechanistic basis for the control of FPR expression in normal peritumoral versus tumoral tissues could provide the basis for new diagnostic and therapeutic interventions. Copyright
BACKGROUND/AIM: Formyl-peptide receptors (FPRs) are expressed in several tissues and cell types. The identification of markers involved in cell growth may further allow for molecular profiling of lung cancer. We investigated the possible role of FPRs as molecular markers in several types of lung carcinomas which is the main cause of cancer death worldwide. MATERIALS AND METHODS: Tumor tissue samples were collected from six patients affected by lung cancer. Biopsies were analyzed for expression of FPR isoforms both in tumoral and peritumoral tissue by real-time polymerase chain reaction (PCR), western blot and immunofluorescence. RESULTS: Real-time PCR, western blot and immunofluorescence analyses showed that FPR expression is lower in types of humanlung cancer tissues when compared to the surrounding peritumoral tissues. CONCLUSION: The study of the mechanistic basis for the control of FPR expression in normal peritumoral versus tumoral tissues could provide the basis for new diagnostic and therapeutic interventions. Copyright
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