| Literature DB >> 25964451 |
Nicholas C Grassly1, Gagandeep Kang2, Beate Kampmann3.
Abstract
The reason for holding a meeting to discuss biological challenges to vaccines is simple: not all vaccines work equally well in all settings. This special issue reviews the performance of vaccines in challenging environments, summarizes current thinking on the reasons why vaccines underperform and considers what approaches are necessary to understand the heterogeneity in responses and to improve vaccine immunogenicity and efficacy.Entities:
Keywords: immunization; immunology; infectious disease; vaccine; vaccinology
Mesh:
Substances:
Year: 2015 PMID: 25964451 PMCID: PMC4527384 DOI: 10.1098/rstb.2014.0138
Source DB: PubMed Journal: Philos Trans R Soc Lond B Biol Sci ISSN: 0962-8436 Impact factor: 6.237