Literature DB >> 25964279

Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension.

John J Ryan1, Stephen L Archer2.   

Abstract

Entities:  

Keywords:  glucose oxidation; glycolysis; heart failure; hypertension, pulmonary; mitochondria; mitochondrial dynamics; positron emission tomography

Mesh：

Substances：

Year:  2015        PMID： 25964279      PMCID： PMC4429908          DOI： 10.1161/CIRCULATIONAHA.114.006979

Source DB:  PubMed          Journal:  Circulation        ISSN： 0009-7322            Impact factor:   29.690


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  82 in total

1.  Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply.

Authors:  M C Sugden; M L Langdown; R A Harris; M J Holness
Journal:  Biochem J       Date:  2000-12-15       Impact factor: 3.857

2.  Impaired left ventricular myocardial metabolism in patients with pulmonary hypertension detected by radionuclide imaging.

Authors:  N Nagaya; T Satoh; Y Ishida; M Uematsu; Y Hirose; Y Okano; S Kyotani; N Nakanishi; T Katafuchi; T Kunieda
Journal:  Nucl Med Commun       Date:  1997-12       Impact factor: 1.690

3.  Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia.

Authors:  Sonny O Ang; Hua Chen; Kiichi Hirota; Victor R Gordeuk; Jaroslav Jelinek; Yongli Guan; Enli Liu; Adelina I Sergueeva; Galina Y Miasnikova; David Mole; Patrick H Maxwell; David W Stockton; Gregg L Semenza; Josef T Prchal
Journal:  Nat Genet       Date:  2002-11-04       Impact factor: 38.330

4.  PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation.

Authors:  Emily C Dunford; Eric A Herbst; Nam Ho Jeoung; William Gittings; J Greig Inglis; Rene Vandenboom; Paul J LeBlanc; Robert A Harris; Sandra J Peters
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2011-03-16       Impact factor: 3.619

5.  Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension.

Authors:  Gopinath Sutendra; Sebastien Bonnet; Gael Rochefort; Alois Haromy; Karalyn D Folmes; Gary D Lopaschuk; Jason R B Dyck; Evangelos D Michelakis
Journal:  Sci Transl Med       Date:  2010-08-11       Impact factor: 17.956

6.  Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.

Authors:  Glenn Marsboom; Peter T Toth; John J Ryan; Zhigang Hong; Xichen Wu; Yong-Hu Fang; Thenappan Thenappan; Lin Piao; Hannah J Zhang; Jennifer Pogoriler; Yimei Chen; Erik Morrow; E Kenneth Weir; Jalees Rehman; Stephen L Archer
Journal:  Circ Res       Date:  2012-04-17       Impact factor: 17.367

7.  FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.

Authors:  Lin Piao; Vaninder K Sidhu; Yong-Hu Fang; John J Ryan; Kishan S Parikh; Zhigang Hong; Peter T Toth; Erik Morrow; Shelby Kutty; Gary D Lopaschuk; Stephen L Archer
Journal:  J Mol Med (Berl)       Date:  2012-12-18       Impact factor: 4.599

8.  Right coronary autoregulation in conscious, chronically instrumented dogs.

Authors:  X Bian; A G Williams; P A Gwirtz; H F Downey
Journal:  Am J Physiol       Date:  1998-07

9.  A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted.

Authors:  Jayan Nagendran; Vikram Gurtu; David Z Fu; Jason R B Dyck; Al Haromy; David B Ross; Ivan M Rebeyka; Evangelos D Michelakis
Journal:  J Thorac Cardiovasc Surg       Date:  2008-05-23       Impact factor: 5.209

10.  Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis.

Authors:  Michael A Dengler; Annette M Staiger; Matthias Gutekunst; Ute Hofmann; Malgorzata Doszczak; Peter Scheurich; Matthias Schwab; Walter E Aulitzky; Heiko van der Kuip
Journal:  PLoS One       Date:  2011-09-20       Impact factor: 3.240
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  63 in total

1.  Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects.

Authors:  Xinping Chen; Eric D Austin; Megha Talati; Joshua P Fessel; Eric H Farber-Eger; Evan L Brittain; Anna R Hemnes; James E Loyd; James West
Journal:  Eur Respir J       Date:  2017-08-03       Impact factor: 16.671

2.  Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease.

Authors:  Evgeny A Zemskov; Qing Lu; Wojciech Ornatowski; Christina N Klinger; Ankit A Desai; Emin Maltepe; Jason X-J Yuan; Ting Wang; Jeffrey R Fineman; Stephen M Black
Journal:  Antioxid Redox Signal       Date:  2019-03-19       Impact factor: 8.401

3.  Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling.

Authors:  Rebecca Johnson Kameny; Sanjeev A Datar; Jason B Boehme; Catherine Morris; Terry Zhu; Brian D Goudy; Eric G Johnson; Csaba Galambos; Gary W Raff; Xutong Sun; Ting Wang; Samuel R Chiacchia; Qing Lu; Stephen M Black; Emin Maltepe; Jeffrey R Fineman
Journal:  Am J Respir Cell Mol Biol       Date:  2019-05       Impact factor: 6.914

4.  TWISTed HIF: revisiting smooth muscle HIF-1α signaling in pulmonary hypertension.

Authors:  Yuanjun Steven Shen; Elena A Goncharova
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2018-07-05       Impact factor: 5.464

5.  Rats with a Human Mutation of NFU1 Develop Pulmonary Hypertension.

Authors:  Maki Niihori; Cody A Eccles; Sergey Kurdyukov; Marina Zemskova; Mathews Valuparampil Varghese; Anna A Stepanova; Alexander Galkin; Ruslan Rafikov; Olga Rafikova
Journal:  Am J Respir Cell Mol Biol       Date:  2020-02       Impact factor: 6.914

6.  Abnormal Glucose Metabolism and High-Energy Expenditure in Idiopathic Pulmonary Arterial Hypertension.

Authors:  Gustavo A Heresi; Steven K Malin; Jarrod W Barnes; Liping Tian; John P Kirwan; Raed A Dweik
Journal:  Ann Am Thorac Soc       Date:  2017-02

7.  Diabetes Mellitus Associates with Increased Right Ventricular Afterload and Remodeling in Pulmonary Arterial Hypertension.

Authors:  Morgan E Whitaker; Vineet Nair; Shripad Sinari; Parinita A Dherange; Balaji Natarajan; Lindsey Trutter; Evan L Brittain; Anna R Hemnes; Eric D Austin; Kumar Patel; Stephen M Black; Joe G N Garcia; Jason X Yuan Md PhD; Rebecca R Vanderpool; Franz Rischard; Ayako Makino; Edward J Bedrick; Ankit A Desai
Journal:  Am J Med       Date:  2018-02-05       Impact factor: 4.965

8.  Translational Advances in the Field of Pulmonary Hypertension Molecular Medicine of Pulmonary Arterial Hypertension. From Population Genetics to Precision Medicine and Gene Editing.

Authors:  Eric D Austin; James West; James E Loyd; Anna R Hemnes
Journal:  Am J Respir Crit Care Med       Date:  2017-01-01       Impact factor: 21.405

9.  Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.

Authors:  Olivier Boucherat; Thibaut Peterlini; Alice Bourgeois; Valérie Nadeau; Sandra Breuils-Bonnet; Stéphanie Boilet-Molez; François Potus; Jolyane Meloche; Sophie Chabot; Caroline Lambert; Eve Tremblay; Young Chan Chae; Dario C Altieri; Gopinath Sutendra; Evangelos D Michelakis; Roxane Paulin; Steeve Provencher; Sébastien Bonnet
Journal:  Am J Respir Crit Care Med       Date:  2018-07-01       Impact factor: 21.405

Review 10.  Pulmonary arterial hypertension: pathogenesis and clinical management.

Authors:  Thenappan Thenappan; Mark L Ormiston; John J Ryan; Stephen L Archer
Journal:  BMJ       Date:  2018-03-14
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