Literature DB >> 25964268

FICZ: A Messenger of Light in Human Skin.

Deeba N Syed1, Hasan Mukhtar2.   

Abstract

Photosensitization, subsequent to photon absorption by chromophores present in the human skin, appears to be a key mechanism of UV-induced oxidative stress. The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ), an aryl hydrocarbon receptor ligand, has been found to be a potent UVA photosensitizer, effective at nanomolar concentrations. A novel addition to the family of endogenous photosensitizers, the precise mechanism(s) through which it mediates oxidative stress in UVA exposed skin and its response to the UVB spectrum of the solar UV flux remains unexplored. Further studies related to its functionality in the human skin, its utility as a tool against UV-induced adverse effects, and its role in inflammatory skin diseases will have the potential to open up new avenues in the realms of human skin photobiology.

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Year:  2015        PMID： 25964268     DOI： 10.1038/jid.2015.52

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  22 in total

Review 1.  Photodynamic therapy in dermatology.

Authors:  Chitra S Nayak
Journal:  Indian J Dermatol Venereol Leprol       Date:  2005 May-Jun       Impact factor: 2.545

2.  Cholesterol-rich plasma membrane domains (lipid rafts) in keratinocytes: importance in the baseline and UVA-induced generation of reactive oxygen species.

Authors:  Robert Gniadecki; Nanna Christoffersen; Hans Christian Wulf
Journal:  J Invest Dermatol       Date:  2002-04       Impact factor: 8.551

3.  Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor.

Authors:  Emma Wincent; Johanna Bengtsson; Afshin Mohammadi Bardbori; Tomas Alsberg; Sandra Luecke; Ulf Rannug; Agneta Rannug
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-05       Impact factor: 11.205

4.  DNA damage induced in cells by gamma and UVA radiation as measured by HPLC/GC-MS and HPLC-EC and Comet assay.

Authors:  J P Pouget; T Douki; M J Richard; J Cadet
Journal:  Chem Res Toxicol       Date:  2000-07       Impact factor: 3.739

5.  Fluoroquinolone antibacterials enhance UVA-induced skin tumors.

Authors:  G Klecak; F Urbach; H Urwyler
Journal:  J Photochem Photobiol B       Date:  1997-02       Impact factor: 6.252

Review 6.  Carcinogenic risks of psoralen UV-A therapy and narrowband UV-B therapy in chronic plaque psoriasis: a systematic literature review.

Authors:  E Archier; S Devaux; E Castela; A Gallini; F Aubin; M Le Maître; S Aractingi; H Bachelez; B Cribier; P Joly; D Jullien; L Misery; C Paul; J-P Ortonne; M-A Richard
Journal:  J Eur Acad Dermatol Venereol       Date:  2012-05       Impact factor: 6.166

7.  UVR exposure sensitizes keratinocytes to DNA adduct formation.

Authors:  Sudhir Nair; Vikram D Kekatpure; Benjamin L Judson; Arleen B Rifkind; Richard D Granstein; Jay O Boyle; Kotha Subbaramaiah; Joseph B Guttenplan; Andrew J Dannenberg
Journal:  Cancer Prev Res (Phila)       Date:  2009-09-29

8.  Malassezia yeasts produce a collection of exceptionally potent activators of the Ah (dioxin) receptor detected in diseased human skin.

Authors:  Prokopios Magiatis; Periklis Pappas; George Gaitanis; Nikitia Mexia; Eleni Melliou; Maria Galanou; Christophoros Vlachos; Konstantina Stathopoulou; Alexios Leandros Skaltsounis; Marios Marselos; Aristea Velegraki; Michael S Denison; Ioannis D Bassukas
Journal:  J Invest Dermatol       Date:  2013-02-28       Impact factor: 8.551

9.  Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation.

Authors:  Ellen Fritsche; Claudia Schäfer; Christian Calles; Thorsten Bernsmann; Thorsten Bernshausen; Melanie Wurm; Ulrike Hübenthal; Jason E Cline; Hossein Hajimiragha; Peter Schroeder; Lars-Oliver Klotz; Agneta Rannug; Peter Fürst; Helmut Hanenberg; Josef Abel; Jean Krutmann
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-14       Impact factor: 11.205

10.  Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions.

Authors:  Paola Di Meglio; João H Duarte; Helena Ahlfors; Nick D L Owens; Ying Li; Federica Villanova; Isabella Tosi; Keiji Hirota; Frank O Nestle; Ulrich Mrowietz; Michael J Gilchrist; Brigitta Stockinger
Journal:  Immunity       Date:  2014-06-05       Impact factor: 31.745
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  6 in total

1.  The Endogenous Tryptophan-derived Photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) is a Nanomolar Photosensitizer that Can be Harnessed for the Photodynamic Elimination of Skin Cancer Cells in Vitro and in Vivo.

Authors:  Rebecca Justiniano; Lohanna de Faria Lopes; Jessica Perer; Anh Hua; Sophia L Park; Jana Jandova; Maurício S Baptista; Georg T Wondrak
Journal:  Photochem Photobiol       Date:  2020-09-14       Impact factor: 3.421

Review 2.  Oxidative Stress and Treg and Th17 Dysfunction in Systemic Lupus Erythematosus.

Authors:  Ji Yang; Xue Yang; Hejian Zou; Ming Li
Journal:  Oxid Med Cell Longev       Date:  2016-08-11       Impact factor: 6.543

3.  Effect of Sulforaphane and 5-Aza-2'-Deoxycytidine on Melanoma Cell Growth.

Authors:  Tung-Chin Chiang; Brian Koss; L Joseph Su; Charity L Washam; Stephanie D Byrum; Aaron Storey; Alan J Tackett
Journal:  Medicines (Basel)       Date:  2019-06-27

4.  Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor.

Authors:  Cunyu Zhang; Katrina L Creech; William J Zuercher; Timothy M Willson
Journal:  Sci Rep       Date:  2019-07-10       Impact factor: 4.379

5.  Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor.

Authors:  Aayushi Uberoi; Casey Bartow-McKenney; Qi Zheng; Laurice Flowers; Amy Campbell; Simon A B Knight; Neal Chan; Monica Wei; Victoria Lovins; Julia Bugayev; Joseph Horwinski; Charles Bradley; Jason Meyer; Debra Crumrine; Carrie Hayes Sutter; Peter Elias; Elizabeth Mauldin; Thomas R Sutter; Elizabeth A Grice
Journal:  Cell Host Microbe       Date:  2021-07-01       Impact factor: 31.316

6.  Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells-In Vitro Studies.

Authors:  Katarzyna Walczak; Ewa Langner; Anna Makuch-Kocka; Monika Szelest; Karolina Szalast; Sebastian Marciniak; Tomasz Plech
Journal:  Int J Mol Sci       Date:  2020-10-26       Impact factor: 5.923
  6 in total

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