Literature DB >> 25964266

Docosahexaenoic Acid alleviates atopic dermatitis in mice by generating T regulatory cells and m2 macrophages.

Karyn A Haitz1, Niroshana Anandasabapathy2.   

Abstract

Han et al. (this issue) describe a novel mechanism by which docosahexaenoic acid (DHA) may suppress atopic dermatitis symptoms in mice. They find that DHA induces FoxP3 T regulatory cells in vivo, M2 macrophages drive transforming growth factor-β and IL-10 conversion of CD4 T cells to CD4 FoxP3 T regulatory cells in vitro, and DHA-treated M2 macrophages suppress atopic dermatitis in mice.

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Year:  2015        PMID： 25964266     DOI： 10.1038/jid.2014.536

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  21 in total

1.  Correction of the cutaneous manifestations of essential fatty acid deficiency in man by application of sunflower-seed oil to the skin.

Authors:  C Prottey; P J Hartop; M Press
Journal:  J Invest Dermatol       Date:  1975-04       Impact factor: 8.551

2.  Nutrition classics from The Journal of Biological Chemistry 82:345-67, 1929. A new deficiency disease produced by the rigid exclusion of fat from the diet.

Authors:  G O Burr; M M Burr
Journal:  Nutr Rev       Date:  1973-08       Impact factor: 7.110

3.  Docosahexaenoic Acid Alleviates Atopic Dermatitis by Generating Tregs and IL-10/TGF-β-Modified Macrophages via a TGF-β-Dependent Mechanism.

Authors:  Sang-Chul Han; Dong-Hwan Koo; Na-Jin Kang; Weon-Jong Yoon; Gyeoung-Jin Kang; Hee-Kyoung Kang; Eun-Sook Yoo
Journal:  J Invest Dermatol       Date:  2014-11-18       Impact factor: 8.551

4.  Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

Authors:  Philip C Calder
Journal:  Br J Clin Pharmacol       Date:  2013-03       Impact factor: 4.335

5.  Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers.

Authors:  Erik Hjorth; Mingqin Zhu; Veronica Cortés Toro; Inger Vedin; Jan Palmblad; Tommy Cederholm; Yvonne Freund-Levi; Gerd Faxen-Irving; Lars-Olof Wahlund; Hans Basun; Maria Eriksdotter; Marianne Schultzberg
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472

Review 6.  Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease.

Authors:  John W C Sijben; Philip C Calder
Journal:  Proc Nutr Soc       Date:  2007-05       Impact factor: 6.297

7.  Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study.

Authors:  Inger Vedin; Tommy Cederholm; Yvonne Freund Levi; Hans Basun; Anita Garlind; Gerd Faxén Irving; Maria Eriksdotter Jönhagen; Bengt Vessby; Lars-Olof Wahlund; Jan Palmblad
Journal:  Am J Clin Nutr       Date:  2008-06       Impact factor: 7.045

8.  Docosahexaenoic acid (DHA) supplementation in atopic eczema: a randomized, double-blind, controlled trial.

Authors:  C Koch; S Dölle; M Metzger; C Rasche; H Jungclas; R Rühl; H Renz; M Worm
Journal:  Br J Dermatol       Date:  2008-01-30       Impact factor: 9.302

Review 9.  Atopic dermatitis: a disease of altered skin barrier and immune dysregulation.

Authors:  Mark Boguniewicz; Donald Y M Leung
Journal:  Immunol Rev       Date:  2011-07       Impact factor: 12.988

10.  Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo.

Authors:  Paul S Noakes; Maria Vlachava; Lefkothea-Stella Kremmyda; Norma D Diaper; Elizabeth A Miles; Mich Erlewyn-Lajeunesse; Anthony P Williams; Keith M Godfrey; Philip C Calder
Journal:  Am J Clin Nutr       Date:  2012-01-04       Impact factor: 7.045
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  6 in total

1.  Coenzyme Q10 Suppresses TNF-α-Induced Inflammatory Reaction In Vitro and Attenuates Severity of Dermatitis in Mice.

Authors:  Weiwei Li; Xiaojuan Wu; Xiangling Xu; Wenhan Wang; Sijia Song; Ke Liang; Min Yang; Linlin Guo; Yunpeng Zhao; Ruifeng Li
Journal:  Inflammation       Date:  2016-02       Impact factor: 4.092

2.  Post-stroke DHA Treatment Protects Against Acute Ischemic Brain Injury by Skewing Macrophage Polarity Toward the M2 Phenotype.

Authors:  Wei Cai; Sanxin Liu; Mengyan Hu; Xiaobo Sun; Wei Qiu; Songguo Zheng; Xiaoming Hu; Zhengqi Lu
Journal:  Transl Stroke Res       Date:  2018-09-10       Impact factor: 6.829

Review 3.  Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation.

Authors:  Bodo C Melnik; Swen Malte John; Pedro Carrera-Bastos; Gerd Schmitz
Journal:  Clin Transl Allergy       Date:  2016-05-12       Impact factor: 5.871

Review 4.  Effects of Omega-3 Fatty Acids on Immune Cells.

Authors:  Saray Gutiérrez; Sara L Svahn; Maria E Johansson
Journal:  Int J Mol Sci       Date:  2019-10-11       Impact factor: 5.923

5.  Regulatory T Cell Induced by Poria cocos Bark Exert Therapeutic Effects in Murine Models of Atopic Dermatitis and Food Allergy.

Authors:  Min-Jung Bae; Hye-Jeong See; Gyeyoung Choi; Chang-Yuil Kang; Dong-Hwa Shon; Hee Soon Shin
Journal:  Mediators Inflamm       Date:  2016-06-29       Impact factor: 4.711

6.  N-3 polyunsaturated fatty acids restore Th17 and Treg balance in collagen antibody-induced arthritis.

Authors:  Ji Young Kim; Kyu Lim; Kyung Hee Kim; Jin Hyun Kim; Jin Sun Choi; Seung-Cheol Shim
Journal:  PLoS One       Date:  2018-03-15       Impact factor: 3.240
  6 in total

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