H Colak1, S Ersan2, M Tanrisev2, Y Kurtulmus3, P Degirmenci4, S Comert4, C Tugmen5, C Ceylan6. 1. Department of Nephrology, Tepecik Training and Research Hospital, Izmir, Turkey. Electronic address: bahadirh76@hotmail.com. 2. Department of Nephrology, Tepecik Training and Research Hospital, Izmir, Turkey. 3. Tissue Typing Laboratory, Tepecik Training and Research Hospital, Izmir, Turkey. 4. Department of Allergy and Immunology, Tepecik Training and Research Hospital, Izmir, Turkey. 5. Department of Surgery, Tepecik Training and Research Hospital, Izmir, Turkey. 6. Department of Hematology, Tepecik Training and Research Hospital, Izmir, Turkey.
Abstract
INTRODUCTION: We evaluated the relationship of interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) levels with graft function in kidney transplantation patients receiving tacrolimus-based immunosuppression during the early post-transplantation period. MATERIAL AND METHODS: There were 112 patients who underwent kidney transplantation from live donors between May 2011 and May 2013. Eight patients had at least 1 of the exclusion criteria, and the remaining 104 patients were included in the study. The recipients underwent evaluation for biochemical markers, complete blood count, and creatinine and cytokine (IL-10, TGF-β) levels during the pretransplantation and post-transplantation 6 months. RESULTS: The creatinine level was negatively correlated with IL-10 and positively correlated with TGF-β levels in both the pretransplantation and early post-transplantation period. CONCLUSION: Low serum TGF-β and high IL-10 levels at post-transplantation month 6 might have a positive effect on graft survival in living donor kidney recipients on tacrolimus-based immunosuppressive treatment.
INTRODUCTION: We evaluated the relationship of interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) levels with graft function in kidney transplantation patients receiving tacrolimus-based immunosuppression during the early post-transplantation period. MATERIAL AND METHODS: There were 112 patients who underwent kidney transplantation from live donors between May 2011 and May 2013. Eight patients had at least 1 of the exclusion criteria, and the remaining 104 patients were included in the study. The recipients underwent evaluation for biochemical markers, complete blood count, and creatinine and cytokine (IL-10, TGF-β) levels during the pretransplantation and post-transplantation 6 months. RESULTS: The creatinine level was negatively correlated with IL-10 and positively correlated with TGF-β levels in both the pretransplantation and early post-transplantation period. CONCLUSION: Low serum TGF-β and high IL-10 levels at post-transplantation month 6 might have a positive effect on graft survival in living donor kidney recipients on tacrolimus-based immunosuppressive treatment.