Shota Nakamura1, Takayuki Fukui2, Koji Kawaguchi2, Koichi Fukumoto2, Akihiro Hirakawa2, Kohei Yokoi2. 1. Department of Thoracic Surgery, and Biostatistics and Bioinformatics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: shota197065@med.nagoya-u.ac.jp. 2. Department of Thoracic Surgery, and Biostatistics and Bioinformatics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Abstract
INTRODUCTION: Recent studies have demonstrated that ground glass opacity (GGO)-dominant tumors correspond to pathologically low-grade adenocarcinomas and that patients with resected tumors have an excellent prognosis. However, almost all of those studies were limited to tumors measuring ≤3.0cm. The purpose of this study was to characterize lung adenocarcinomas >3.0cm in diameter with GGO-dominant features and evaluate the prognosis of patients with such tumors. METHODS: One hundred and thirteen patients with cT2aN0M0 lung adenocarcinoma underwent surgical resection between 2005 and 2011. Twenty-five had tumors with a ≥50% GGO component (GGO-dominant group) and the remaining had solid-dominant tumors (Solid-dominant group). The clinicopathological findings and prognosis of the two groups were evaluated. RESULTS: The tumors in the GGO-dominant group rarely exhibited pathological invasiveness, such as lymphatic (n=1), vascular (n=0) and pleural invasion (n=5) or lymph node metastasis (n=0). On the other hand, the tumors in the solid-dominant group frequently exhibited pathological invasiveness, including lymphatic (n=26), vascular (n=16) and plural invasion (n=52) and lymph node metastasis (n=18). There were significant differences in all of the characteristics between the two groups (lymphatic; p=0.0026, vascular; p=0.0214, and pleural invasion; p=0.0004, and lymph node metastases; p=0.0086, respectively). In the GGO-dominant group, 24 patients were alive without recurrence, while the remaining died of another cancer. Recurrence occurred in 34 patients in the solid-dominant group, and 16 died of the disease. The 5-year survival rate was 96% in the GGO-dominant group, compared to 71% in the solid-dominant group (p=0.0120). CONCLUSIONS: In the GGO-dominant group, the malignant potential was low and the patients had a favorable prognosis after surgery, similar to the patients with GGO-dominant tumors diagnosed as cT1a-bN0M0.
INTRODUCTION: Recent studies have demonstrated that ground glass opacity (GGO)-dominant tumors correspond to pathologically low-grade adenocarcinomas and that patients with resected tumors have an excellent prognosis. However, almost all of those studies were limited to tumors measuring ≤3.0cm. The purpose of this study was to characterize lung adenocarcinomas >3.0cm in diameter with GGO-dominant features and evaluate the prognosis of patients with such tumors. METHODS: One hundred and thirteen patients with cT2aN0M0 lung adenocarcinoma underwent surgical resection between 2005 and 2011. Twenty-five had tumors with a ≥50% GGO component (GGO-dominant group) and the remaining had solid-dominant tumors (Solid-dominant group). The clinicopathological findings and prognosis of the two groups were evaluated. RESULTS: The tumors in the GGO-dominant group rarely exhibited pathological invasiveness, such as lymphatic (n=1), vascular (n=0) and pleural invasion (n=5) or lymph node metastasis (n=0). On the other hand, the tumors in the solid-dominant group frequently exhibited pathological invasiveness, including lymphatic (n=26), vascular (n=16) and plural invasion (n=52) and lymph node metastasis (n=18). There were significant differences in all of the characteristics between the two groups (lymphatic; p=0.0026, vascular; p=0.0214, and pleural invasion; p=0.0004, and lymph node metastases; p=0.0086, respectively). In the GGO-dominant group, 24 patients were alive without recurrence, while the remaining died of another cancer. Recurrence occurred in 34 patients in the solid-dominant group, and 16 died of the disease. The 5-year survival rate was 96% in the GGO-dominant group, compared to 71% in the solid-dominant group (p=0.0120). CONCLUSIONS: In the GGO-dominant group, the malignant potential was low and the patients had a favorable prognosis after surgery, similar to the patients with GGO-dominant tumors diagnosed as cT1a-bN0M0.
Authors: Hyung-Jun Kim; Jun Yeun Cho; Yeon Joo Lee; Jong Sun Park; Young-Jae Cho; Ho Il Yoon; Jin-Haeng Chung; Sukki Cho; Kwhanmien Kim; Kyung Won Lee; Jae Ho Lee; Choon-Taek Lee Journal: Cancer Res Treat Date: 2019-03-25 Impact factor: 4.679