Benjamin Chaigne1, Gérard Lasfargues2, Isabelle Marie3, Brigitte Hüttenberger4, Christian Lavigne5, Sylvain Marchand-Adam6, François Maillot7, Elisabeth Diot7. 1. CHRU de Tours, Service de Médecine Interne, Université François-Rabelais de Tours, France. Electronic address: benjamin.chaigne@hotmail.fr. 2. Institut de Santé au travail de Paris-Est, Université Paris-Est Créteil, France. 3. CHRU de Rouen, Service de Médecine Interne, Rouen, France. 4. CHRU de Tours, Service de Stomatologie et de Chirurgie Maxillo-Faciale, Tours, France. 5. CHRU d'Angers, Service de Médecine Interne, Angers, France. 6. CHRU de Tours, Service de Pneumologie, Université François-Rabelais de Tours, France. 7. CHRU de Tours, Service de Médecine Interne, Université François-Rabelais de Tours, France.
Abstract
OBJECTIVES: A case-control study was carried out to investigate the relation between primary Sjögren's syndrome (pSS) and occupational exposure. METHODS: One hundred seventy five cases of pSS followed up into the internal medicine departments of three French university hospitals from 2010 to 2013 were included. For each case, two age and gender matched controls were selected during the same period in the same departments. Occupational exposure was assessed retrospectively by industrial hygienists and occupational practitioners. Exposure to occupational factors such as organic solvents or silica was investigated using semiquantitative estimates of exposure. An exposure score was calculated for each subject based on probability, intensity, daily frequency, and duration of exposure for each period of employment. The final cumulative exposure score was obtained, taking into account all periods of employment. RESULTS: Significant associations with pSS were observed for dichloromethane (OR 9.28, 95%CI 2.60-33.03), perchlorethylene (OR 2.64, 95%CI 1.20-5.77) chlorinated solvents (OR 2.95, 95%CI 1.77-4.93), benzene (OR 3.30, 95%CI 1.07-10.26), toluene (OR 4.18 95%CI 1.41-12.43), white spirit (OR 3.60, 95%CI 1.39-9.33), aromatic solvents (OR 3.03, 95%CI 1.41-6.50) and any types of solvents (OR 2.76, 95%CI 1.70-4.47). Risk of pSS was significantly associated with a high cumulative exposure score of occupational exposure to toluene (OR 4.69, 95%CI 1.42-15.45), white spirit (OR 3.30, 95%CI 1.07-10.26), aromatic solvents (OR 2.50, 95%CI 1.06-5.91) and any types of solvents (OR 2.25, 95%CI 1.20-4.22). CONCLUSION: This work suggests the influence of occupational risk factors in the occurrence of pSS.
OBJECTIVES: A case-control study was carried out to investigate the relation between primary Sjögren's syndrome (pSS) and occupational exposure. METHODS: One hundred seventy five cases of pSS followed up into the internal medicine departments of three French university hospitals from 2010 to 2013 were included. For each case, two age and gender matched controls were selected during the same period in the same departments. Occupational exposure was assessed retrospectively by industrial hygienists and occupational practitioners. Exposure to occupational factors such as organic solvents or silica was investigated using semiquantitative estimates of exposure. An exposure score was calculated for each subject based on probability, intensity, daily frequency, and duration of exposure for each period of employment. The final cumulative exposure score was obtained, taking into account all periods of employment. RESULTS: Significant associations with pSS were observed for dichloromethane (OR 9.28, 95%CI 2.60-33.03), perchlorethylene (OR 2.64, 95%CI 1.20-5.77) chlorinated solvents (OR 2.95, 95%CI 1.77-4.93), benzene (OR 3.30, 95%CI 1.07-10.26), toluene (OR 4.18 95%CI 1.41-12.43), white spirit (OR 3.60, 95%CI 1.39-9.33), aromatic solvents (OR 3.03, 95%CI 1.41-6.50) and any types of solvents (OR 2.76, 95%CI 1.70-4.47). Risk of pSS was significantly associated with a high cumulative exposure score of occupational exposure to toluene (OR 4.69, 95%CI 1.42-15.45), white spirit (OR 3.30, 95%CI 1.07-10.26), aromatic solvents (OR 2.50, 95%CI 1.06-5.91) and any types of solvents (OR 2.25, 95%CI 1.20-4.22). CONCLUSION: This work suggests the influence of occupational risk factors in the occurrence of pSS.
Authors: Stéphanie Jobard; Benjamin Chaigne; Sylvain Marchand-Adam; Gérard Lasfargues; Elisabeth Diot Journal: Int Arch Occup Environ Health Date: 2017-08-01 Impact factor: 3.015
Authors: Signe Hjuler Boudigaard; Zara Ann Stokholm; Jesper Medom Vestergaard; Mette Skovgaard Mohr; Klaus Søndergaard; Kjell Torén; Vivi Schlünssen; Henrik A Kolstad Journal: Occup Environ Med Date: 2019-12-17 Impact factor: 4.402