Literature DB >> 25962336

Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control.

Suwei Zhu1, Lina Nih1, S Thomas Carmichael2, Yunfeng Lu1, Tatiana Segura1.   

Abstract

Orchestrated biological materials such as enzymes and growth factors regulate the growth of tissues and organs. A chirality-controlled, single-protein technology is devised to tailor the spatiotemporally defined delivery of therapeutic proteins in response to natural enzymes present at wound sites. Sustained delivery of one protein and sequential delivery of two proteins are demonstrated for stroke and skin wound healing.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  chiral peptides; enzyme responsive; protein delivery; sequential release; wound healing

Mesh：

Substances：

Year:  2015        PMID： 25962336      PMCID： PMC4633528          DOI： 10.1002/adma.201500417

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  23 in total

1.  Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis.

Authors:  Clare R Ozawa; Andrea Banfi; Nicole L Glazer; Gavin Thurston; Matthew L Springer; Peggy E Kraft; Donald M McDonald; Helen M Blau
Journal:  J Clin Invest       Date:  2004-02       Impact factor: 14.808

2.  Polymeric system for dual growth factor delivery.

Authors:  T P Richardson; M C Peters; A B Ennett; D J Mooney
Journal:  Nat Biotechnol       Date:  2001-11       Impact factor: 54.908

Review 3.  Proteolytic enzymes in wound healing: the role of enzymatic debridement.

Authors:  R D Sinclair; T J Ryan
Journal:  Australas J Dermatol       Date:  1994       Impact factor: 2.875

4.  Temporal expression of urokinase plasminogen activator, plasminogen activator inhibitor and gelatinase-B in chronic wound fluid switches from a chronic to acute wound profile with progression to healing.

Authors:  A B Wysocki; A O Kusakabe; S Chang; T L Tuan
Journal:  Wound Repair Regen       Date:  1999 May-Jun       Impact factor: 3.617

5.  VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain.

Authors:  Z G Zhang; L Zhang; Q Jiang; R Zhang; K Davies; C Powers; N v Bruggen; M Chopp
Journal:  J Clin Invest       Date:  2000-10       Impact factor: 14.808

6.  PDGF and FGF stimulate wound healing in the genetically diabetic mouse.

Authors:  D G Greenhalgh; K H Sprugel; M J Murray; R Ross
Journal:  Am J Pathol       Date:  1990-06       Impact factor: 4.307

7.  Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing.

Authors:  S Frank; G Hübner; G Breier; M T Longaker; D G Greenhalgh; S Werner
Journal:  J Biol Chem       Date:  1995-05-26       Impact factor: 5.157

8.  Growth and fibrinolytic parameters of human umbilical vein endothelial cells seeded onto cardiovascular grafts.

Authors:  J C Zhang; J Wojta; B R Binder
Journal:  J Thorac Cardiovasc Surg       Date:  1995-06       Impact factor: 5.209

9.  Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells.

Authors:  Robert D Galiano; Oren M Tepper; Catherine R Pelo; Kirit A Bhatt; Matthew Callaghan; Nicholas Bastidas; Stuart Bunting; Hope G Steinmetz; Geoffrey C Gurtner
Journal:  Am J Pathol       Date:  2004-06       Impact factor: 4.307

10.  MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing.

Authors:  D Seliktar; A H Zisch; M P Lutolf; J L Wrana; J A Hubbell
Journal:  J Biomed Mater Res A       Date:  2004-03-15       Impact factor: 4.396
View more
  20 in total

Review 1.  Hydrogels for brain repair after stroke: an emerging treatment option.

Authors:  Lina Ratiba Nih; Stanley Thomas Carmichael; Tatiana Segura
Journal:  Curr Opin Biotechnol       Date:  2016-05-07       Impact factor: 9.740

2.  Injection of Microporous Annealing Particle (MAP) Hydrogels in the Stroke Cavity Reduces Gliosis and Inflammation and Promotes NPC Migration to the Lesion.

Authors:  Lina R Nih; Elias Sideris; S Thomas Carmichael; Tatiana Segura
Journal:  Adv Mater       Date:  2017-06-26       Impact factor: 30.849

Review 3.  Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications.

Authors:  Hussein M El-Husseiny; Eman A Mady; Lina Hamabe; Amira Abugomaa; Kazumi Shimada; Tomohiko Yoshida; Takashi Tanaka; Aimi Yokoi; Mohamed Elbadawy; Ryou Tanaka
Journal:  Mater Today Bio       Date:  2021-12-09

4.  Wearable Bioelectronics for Chronic Wound Management.

Authors:  Canran Wang; Ehsan Shirzaei Sani; Wei Gao
Journal:  Adv Funct Mater       Date:  2021-12-26       Impact factor: 19.924

5.  Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain.

Authors:  Pouria Moshayedi; Lina R Nih; Irene L Llorente; Andrew R Berg; Jessica Cinkornpumin; William E Lowry; Tatiana Segura; S Thomas Carmichael
Journal:  Biomaterials       Date:  2016-08-02       Impact factor: 12.479

Review 6.  Glycosaminoglycan-Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials.

Authors:  Uwe Freudenberg; Yingkai Liang; Kristi L Kiick; Carsten Werner
Journal:  Adv Mater       Date:  2016-07-27       Impact factor: 30.849

7.  Cell-Demanded VEGF Release via Nanocapsules Elicits Different Receptor Activation Dynamics and Enhanced Angiogenesis.

Authors:  Suwei Zhu; Tatiana Segura
Journal:  Ann Biomed Eng       Date:  2016-03-03       Impact factor: 3.934

8.  Systematic evaluation of natural scaffolds in cutaneous wound healing.

Authors:  Cynthia Cam; Suwei Zhu; Norman F Truong; Philip O Scumpia; Tatiana Segura
Journal:  J Mater Chem B       Date:  2015-08-21       Impact factor: 6.331

9.  Functionalized helical fibre bundles of carbon nanotubes as electrochemical sensors for long-term in vivo monitoring of multiple disease biomarkers.

Authors:  Liyuan Wang; Songlin Xie; Zhiyuan Wang; Fei Liu; Yifan Yang; Chengqiang Tang; Xiaoying Wu; Peng Liu; Yongjing Li; Hexige Saiyin; Shuang Zheng; Xuemei Sun; Fan Xu; Hongbo Yu; Huisheng Peng
Journal:  Nat Biomed Eng       Date:  2019-10-28       Impact factor: 25.671

Review 10.  Stimuli-Responsive Delivery of Growth Factors for Tissue Engineering.

Authors:  Moyuan Qu; Xing Jiang; Xingwu Zhou; Canran Wang; Qingzhi Wu; Li Ren; Jixiang Zhu; Songsong Zhu; Peyton Tebon; Wujin Sun; Ali Khademhosseini
Journal:  Adv Healthc Mater       Date:  2020-03-03       Impact factor: 9.933
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.