Rifins, rosetting, and red blood cells.

The binding of multiple uninfected erythrocytes to a central malaria parasite-infected erythrocyte (IE) is called rosetting. Rosetting has been associated with severe disease, but its functional significance,and the host receptors and parasite ligands involved are only partially known. A recent study, which describes yet another piece in this already complex puzzle, provides a welcome boost and a broadening of an important malaria research field.