Ram R Miller1, Marty Eastlack2, Gregory E Hicks3, Dawn E Alley4, Michelle D Shardell5, Denise L Orwig4, Bret H Goodpaster6, Peter J Chomentowski6, William G Hawkes4, Marc C Hochberg7, Luigi Ferrucci8, Jay Magaziner4. 1. GlaxoSmithKline, Research Triangle Park, North Carolina Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore ram.6.miller@gsk.com. 2. Department of Physical Therapy, Arcadia University, Glenside, Pennsylvania. 3. Department of Physical Therapy, University of Delaware, Newark. 4. Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore. 5. Division of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore. 6. Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pennsylvania. 7. Department of Medicine, University of Maryland School of Medicine, Baltimore. 8. Longitudinal Studies Section, National Institute on Aging, Baltimore, Maryland.
Abstract
BACKGROUND: Hip fracture is an important problem for older adults with significant functional consequences. After hip fracture, reduced muscle loading can result in muscle atrophy. METHODS: We compared thigh muscle characteristics in the fractured leg with those in the nonfractured leg in participants from the Baltimore Hip Studies 7th cohort using computed tomography (CT) scan imaging. RESULTS: At 2 months postfracture, a single 10-mm axial CT scan was obtained at the midthigh level in 47 participants (26 men and 21 women) with a mean age of 80.4 years (range 65-96), and thigh muscle cross-sectional area (CSA), CSA of intermuscular adipose tissue (IMAT), as well as mean radiological attenuation were measured. Total thigh muscle CSA was less on the side of the fracture by 9.2 cm(2) (95% CI: 5.9, 12.4 cm(2)), whereas the CSA of IMAT was greater by 2.8 cm(2) (95% CI: 1.9, 3.8 cm(2)) on the fractured side. Mean muscle attenuation was lower on the side of the fracture by 3.61 HU (95% CI: 2.99, 4.24 HU). CONCLUSIONS: The observed asymmetry is consistent with the effect of disuse and inflammation in the affected limb along with training effects in the unaffected limb due to the favoring of this leg with ambulation during the postfracture period.
BACKGROUND:Hip fracture is an important problem for older adults with significant functional consequences. After hip fracture, reduced muscle loading can result in muscle atrophy. METHODS: We compared thigh muscle characteristics in the fractured leg with those in the nonfractured leg in participants from the Baltimore Hip Studies 7th cohort using computed tomography (CT) scan imaging. RESULTS: At 2 months postfracture, a single 10-mm axial CT scan was obtained at the midthigh level in 47 participants (26 men and 21 women) with a mean age of 80.4 years (range 65-96), and thigh muscle cross-sectional area (CSA), CSA of intermuscular adipose tissue (IMAT), as well as mean radiological attenuation were measured. Total thigh muscle CSA was less on the side of the fracture by 9.2 cm(2) (95% CI: 5.9, 12.4 cm(2)), whereas the CSA of IMAT was greater by 2.8 cm(2) (95% CI: 1.9, 3.8 cm(2)) on the fractured side. Mean muscle attenuation was lower on the side of the fracture by 3.61 HU (95% CI: 2.99, 4.24 HU). CONCLUSIONS: The observed asymmetry is consistent with the effect of disuse and inflammation in the affected limb along with training effects in the unaffected limb due to the favoring of this leg with ambulation during the postfracture period.
Authors: Anne B Newman; Catherine L Haggerty; Bret Goodpaster; Tamara Harris; Steve Kritchevsky; Michael Nevitt; Toni P Miles; Marjolein Visser Journal: J Am Geriatr Soc Date: 2003-03 Impact factor: 5.562
Authors: Ram R Miller; Michelle D Shardell; Gregory E Hicks; Anne R Cappola; William G Hawkes; Janet A Yu-Yahiro; Jay Magaziner Journal: J Am Geriatr Soc Date: 2008-04-11 Impact factor: 5.562
Authors: Dennis R Taaffe; Tim R Henwood; Michael A Nalls; Duncan G Walker; Thomas F Lang; Tamara B Harris Journal: Gerontology Date: 2008-12-05 Impact factor: 5.140