Hyun Park1, Sang-Wook Yoon2, Amit Sokolov3. 1. Comprehensive Gynecologic Cancer Center, CHA Bundang Medical Center, CHA University, Gyunggi-do, Republic of Korea. 2. Department of Diagnostic Radiology, CHA Bundang Medical Center, CHA University, 351, Yatap-dong, Bundang-gu, Sungnam-si, Gyunggi-do, Republic of Korea, 463-712. jansons@cha.ac.kr. 3. InSightec Ltd., Haifa, Israel.
Abstract
OBJECTIVES: Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) is a non-invasive method to treat uterine fibroids. To help determine the patient suitability for MRgFUS, we propose a new objective measure: the scaled signal intensity (SSI) of uterine fibroids in T2 weighted MR images (T2WI). METHODS: Forty three uterine fibroids in 40 premenopausal women were included in this retrospective study. SSI of each fibroid was measured from the screening T2WI by standardizing its mean signal intensity to a 0-100 scale, using reference intensities of rectus abdominis muscle (0) and subcutaneous fat (100). Correlation between the SSI and the non-perfused volume (NPV) ratio (a measure for treatment success) was calculated. RESULTS: Pre-treatment SSI showed a significant inverse-correlation with post treatment NPV ratio (p < 0.05). When dichotomizing NPV ratio at 45 %, the optimal cut off value of the SSI was found to be 16.0. CONCLUSIONS: A fibroid with SSI value 16.0 or less can be expected to have optimal responses. The SSI of uterine fibroids in T2WI can be suggested as an objective parameter to help in patient selection for MRgFUS. KEY POINTS: • Signal intensity of fibroid in MR images predicts treatment response to MRgFUS. • Signal intensity is standardized into scaled form using adjacent tissues as references. • Fibroids with SSI less than 16.0 are expected to have optimal responses.
OBJECTIVES: Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) is a non-invasive method to treat uterine fibroids. To help determine the patient suitability for MRgFUS, we propose a new objective measure: the scaled signal intensity (SSI) of uterine fibroids in T2 weighted MR images (T2WI). METHODS: Forty three uterine fibroids in 40 premenopausal women were included in this retrospective study. SSI of each fibroid was measured from the screening T2WI by standardizing its mean signal intensity to a 0-100 scale, using reference intensities of rectus abdominis muscle (0) and subcutaneous fat (100). Correlation between the SSI and the non-perfused volume (NPV) ratio (a measure for treatment success) was calculated. RESULTS: Pre-treatment SSI showed a significant inverse-correlation with post treatment NPV ratio (p < 0.05). When dichotomizing NPV ratio at 45 %, the optimal cut off value of the SSI was found to be 16.0. CONCLUSIONS: A fibroid with SSI value 16.0 or less can be expected to have optimal responses. The SSI of uterine fibroids in T2WI can be suggested as an objective parameter to help in patient selection for MRgFUS. KEY POINTS: • Signal intensity of fibroid in MR images predicts treatment response to MRgFUS. • Signal intensity is standardized into scaled form using adjacent tissues as references. • Fibroids with SSI less than 16.0 are expected to have optimal responses.
Entities:
Keywords:
Ablation; Focused ultrasound; Magnetic resonance imaging; Scaled signal intensity; Uterine fibroid
Authors: Nathan McDannold; Clare M Tempany; Fiona M Fennessy; Minna J So; Frank J Rybicki; Elizabeth A Stewart; Ferenc A Jolesz; Kullervo Hynynen Journal: Radiology Date: 2006-07 Impact factor: 11.105
Authors: Zsuzsanna M Lénárd; Nathan J McDannold; Fiona M Fennessy; Elizabeth A Stewart; Ferenc A Jolesz; Kullervo Hynynen; Clare M C Tempany Journal: Radiology Date: 2008-08-11 Impact factor: 11.105
Authors: Elizabeth A Stewart; Bobbie Gostout; Jaron Rabinovici; Hyun S Kim; Lesley Regan; Clare M C Tempany Journal: Obstet Gynecol Date: 2007-08 Impact factor: 7.661
Authors: Fiona M Fennessy; Clare M Tempany; Nathan J McDannold; Minna J So; Gina Hesley; Bobbie Gostout; Hyun S Kim; George A Holland; Dennis A Sarti; Kullervo Hynynen; Ferenc A Jolesz; Elizabeth A Stewart Journal: Radiology Date: 2007-04-19 Impact factor: 11.105
Authors: Kimberley J Anneveldt; Heleen J van 't Oever; Inez M Verpalen; Ingrid M Nijholt; Wilbert Bartels; Jeroen R Dijkstra; Rolf D van den Hoed; Miranda van 't Veer-Ten Kate; Erwin de Boer; Sebastiaan Veersema; Judith A F Huirne; Joke M Schutte; Martijn F Boomsma Journal: Eur J Radiol Open Date: 2022-03-21