Literature DB >> 25956865

BRCA1: Beyond double-strand break repair.

Elizabeth Alli1, James M Ford2.   

Abstract

Since its discovery, the BRCA1 tumor suppressor has been shown to play a role in multiple DNA damage response pathways. Here, we will review the involvement of BRCA1 in base-excision DNA repair and highlight its clinical implications.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  BRCA1; Base-excision repair

Mesh:

Substances:

Year:  2015        PMID: 25956865     DOI: 10.1016/j.dnarep.2015.04.028

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN: 1568-7856


  5 in total

1.  Molecular Analysis of BRCA1 in Human Breast Cancer Cells Under Oxidative Stress.

Authors:  Brian L Gilmore; Yanping Liang; Carly E Winton; Kaya Patel; Vasilea Karageorge; A Cameron Varano; William Dearnaley; Zhi Sheng; Deborah F Kelly
Journal:  Sci Rep       Date:  2017-03-06       Impact factor: 4.379

2.  Impact of Etoposide on BRCA1 Expression in Various Breast Cancer Cell Lines.

Authors:  Xi Zhang; Simone Hofmann; Nadia Harbeck; Udo Jeschke; Sophie Sixou
Journal:  Drugs R D       Date:  2017-12

3.  Structural analysis of BRCA1 reveals modification hotspot.

Authors:  Yanping Liang; William J Dearnaley; A Cameron Varano; Carly E Winton; Brian L Gilmore; Nick A Alden; Zhi Sheng; Deborah F Kelly
Journal:  Sci Adv       Date:  2017-09-20       Impact factor: 14.136

4.  Single-cell analysis of somatic mutation burden in mammary epithelial cells of pathogenic BRCA1/2 mutation carriers.

Authors:  Shixiang Sun; Kristina Brazhnik; Moonsook Lee; Alexander Y Maslov; Yi Zhang; Zhenqiu Huang; Susan Klugman; Ben H Park; Jan Vijg; Cristina Montagna
Journal:  J Clin Invest       Date:  2022-03-01       Impact factor: 14.808

5.  DNA repair prognostic index modelling reveals an essential role for base excision repair in influencing clinical outcomes in ER negative and triple negative breast cancers.

Authors:  Tarek M A Abdel-Fatah; Arvind Arora; Paul M Moseley; Christina Perry; Emad A Rakha; Andrew R Green; Stephen Y T Chan; Ian O Ellis; Srinivasan Madhusudan
Journal:  Oncotarget       Date:  2015-09-08
  5 in total

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