Fernando Moreto1, Hugo T Kano2, Gabriel A Torezan3, Erick P de Oliveira4, Rodrigo M Manda5, Okesley Teixeira6, Edilaine Michelin7, Camila R Correa8, Roberto C Burini9. 1. Sao Paulo State University, Botucatu School of Medicine, Botucatu, Brazil. Electronic address: fer_moreto@yahoo.com.br. 2. Sao Paulo State University, Botucatu School of Medicine, Botucatu, Brazil. Electronic address: hugo.kano@yahoo.com.br. 3. Sao Paulo State University, Botucatu School of Medicine, Botucatu, Brazil. Electronic address: gabrieltorezan@gmail.com. 4. Federal University of Uberlandia, School of Medicine, Uberlandia, Brazil. Electronic address: erick_po@yahoo.com.br. 5. Sao Paulo State University, Botucatu School of Medicine, Botucatu, Brazil. Electronic address: rmanda@fmb.unesp.br. 6. Sao Paulo State University, Botucatu School of Medicine, Botucatu, Brazil. Electronic address: okesley@hotmail.com. 7. Sao Paulo State University, Botucatu School of Medicine, Botucatu, Brazil. Electronic address: edimichelin@yahoo.com.br. 8. Sao Paulo State University, Botucatu School of Medicine, Botucatu, Brazil. Electronic address: ccorrea@fmb.unesp.br. 9. Sao Paulo State University, Botucatu School of Medicine, Botucatu, Brazil. Electronic address: burini@fmb.unesp.br.
Abstract
AIMS: Metabolic syndrome (MetS) is often accompanied by pro-oxidative and pro-inflammatory processes. Lifestyle modification (LiSM) may act as primary treatment for these processes. This study aimed to elucidate influencing factors on changes of malondialdehyde (MDA) and C-reactive protein (CRP) concentrations after a LiSM intervention. METHODS: Sixty subjects (53 yrs, 84% women) clinically approved to attend a 20 weeks LiSM-program were submitted to weekly nutritional counseling and physical activities combining aerobic (3 times/week) and resistance (2 times/week) exercises. Before and after intervention they were assessed for anthropometric, clinical, cardiorespiratory fitness test (CRF) and laboratory markers. Statistical analyses performed were multiple regression analysis and backward stepwise with p<0.05 and R(2) as influence index. RESULTS: LiSM was responsible for elevations in CRF, healthy eating index (HEI), total plasma antioxidant capacity (TAP) and HDL-C along with reductions in waist circumference measures and MetS (47-40%) prevalence. MDA and CRP did not change after LiSM, however, we observed that MDA concentrations were positively influenced (R(2)=0.35) by fasting blood glucose (β=0.64) and HOMA-IR (β=0.58) whereas CRP concentrations were by plasma gamma-glutamyltransferase activity (β=0.54; R(2)=0.29). CONCLUSIONS: Pro-oxidant and pro-inflammatory states of MetS can be attenuated after lifestyle modification if glucose metabolism homeostasis were recovered and if liver inflammation were reduced, respectively.
AIMS: Metabolic syndrome (MetS) is often accompanied by pro-oxidative and pro-inflammatory processes. Lifestyle modification (LiSM) may act as primary treatment for these processes. This study aimed to elucidate influencing factors on changes of malondialdehyde (MDA) and C-reactive protein (CRP) concentrations after a LiSM intervention. METHODS: Sixty subjects (53 yrs, 84% women) clinically approved to attend a 20 weeks LiSM-program were submitted to weekly nutritional counseling and physical activities combining aerobic (3 times/week) and resistance (2 times/week) exercises. Before and after intervention they were assessed for anthropometric, clinical, cardiorespiratory fitness test (CRF) and laboratory markers. Statistical analyses performed were multiple regression analysis and backward stepwise with p<0.05 and R(2) as influence index. RESULTS: LiSM was responsible for elevations in CRF, healthy eating index (HEI), total plasma antioxidant capacity (TAP) and HDL-C along with reductions in waist circumference measures and MetS (47-40%) prevalence. MDA and CRP did not change after LiSM, however, we observed that MDA concentrations were positively influenced (R(2)=0.35) by fasting blood glucose (β=0.64) and HOMA-IR (β=0.58) whereas CRP concentrations were by plasma gamma-glutamyltransferase activity (β=0.54; R(2)=0.29). CONCLUSIONS: Pro-oxidant and pro-inflammatory states of MetS can be attenuated after lifestyle modification if glucose metabolism homeostasis were recovered and if liver inflammation were reduced, respectively.
Authors: Kristin J Meyers; Zhe Liu; Amy E Millen; Sudha K Iyengar; Barbara A Blodi; Elizabeth Johnson; D Max Snodderly; Michael L Klein; Karen M Gehrs; Lesley Tinker; Gloria E Sarto; Jennifer Robinson; Robert B Wallace; Julie A Mares Journal: Ophthalmology Date: 2015-09-06 Impact factor: 12.079