L M Cangussu1, J Nahas-Neto2, C L Orsatti3, F N Bueloni-Dias4, E A P Nahas5. 1. Department of Obstetrics and Gynecology, Botucatu Medical School, Sao Paulo State University-UNESP, Sao Paulo, Brazil. lucianacangussu@gmail.com. 2. Department of Obstetrics and Gynecology, Botucatu Medical School, Sao Paulo State University-UNESP, Sao Paulo, Brazil. netonahas@uol.com.br. 3. Department of Obstetrics and Gynecology, Botucatu Medical School, Sao Paulo State University-UNESP, Sao Paulo, Brazil. claudiorsatti@gmail.com. 4. Department of Obstetrics and Gynecology, Botucatu Medical School, Sao Paulo State University-UNESP, Sao Paulo, Brazil. flaviabueloni@hotmail.com. 5. Department of Obstetrics and Gynecology, Botucatu Medical School, Sao Paulo State University-UNESP, Sao Paulo, Brazil. epetri@fmb.unesp.br.
Abstract
UNLABELLED: The present study investigates the effects of vitamin D on muscle function in postmenopausal women. It has been shown that vitamin D supplementation in postmenopausal women with hypovitaminosis D provides significant protective factor against sarcopenia, with significant increases in muscle strength and control of progressive loss of lean mass. INTRODUCTION: We aimed to evaluate the effect of supplementation of vitamin D (VITD) alone on muscle function in younger postmenopausal women. METHODS: In this double-blind, placebo-controlled clinical trial, 160 Brazilian postmenopausal women were randomized into two groups: VITD group consisting of patients receiving vitamin D3 1000 IU/day orally (n = 80) or placebo group (n = 80). Women with amenorrhea for more than 12 months and age 50-65 years, with a history of falls (previous 12 months), were included. The intervention time was 9 months, with assessments at two points, start and end. Lean mass was estimated by total-body dual-energy X-ray absorptiometry (DXA) and muscle strength by handgrip strength and chair rising test. The plasma concentrations of 25-hydroxyvitamin D [25(OH)D] were measured by high-performance liquid chromatography (HPLC). Statistical analysis was by intention to treat (ITT), using ANOVA, Student's t test, and Tukey's test. RESULTS: After 9 months, average values of 25(OH)D increased from 15.0 ± 7.5 to 27.5 ± 10.4 ng/ml (+45.4%) in the VITD group and decreased from 16.9 ± 6.7 to 13.8 ± 6.0 ng/ml (-18.5%) in the placebo group (p < 0.001). In the VITD group, there was significant increase in muscle strength (+25.3%) of the lower limbs by chair rising test (p = 0.036). In women in the placebo group, there was considerable loss (-6.8%) in the lean mass (p = 0.030). CONCLUSION: The supplementation of vitamin D alone in postmenopausal women provided significant protective factor against the occurrence of sarcopenia, with significant increases in muscle strength and control of progressive loss of lean mass.
RCT Entities:
UNLABELLED: The present study investigates the effects of vitamin D on muscle function in postmenopausal women. It has been shown that vitamin D supplementation in postmenopausal women with hypovitaminosis D provides significant protective factor against sarcopenia, with significant increases in muscle strength and control of progressive loss of lean mass. INTRODUCTION: We aimed to evaluate the effect of supplementation of vitamin D (VITD) alone on muscle function in younger postmenopausal women. METHODS: In this double-blind, placebo-controlled clinical trial, 160 Brazilian postmenopausal women were randomized into two groups: VITD group consisting of patients receiving vitamin D3 1000 IU/day orally (n = 80) or placebo group (n = 80). Women with amenorrhea for more than 12 months and age 50-65 years, with a history of falls (previous 12 months), were included. The intervention time was 9 months, with assessments at two points, start and end. Lean mass was estimated by total-body dual-energy X-ray absorptiometry (DXA) and muscle strength by handgrip strength and chair rising test. The plasma concentrations of 25-hydroxyvitamin D [25(OH)D] were measured by high-performance liquid chromatography (HPLC). Statistical analysis was by intention to treat (ITT), using ANOVA, Student's t test, and Tukey's test. RESULTS: After 9 months, average values of 25(OH)D increased from 15.0 ± 7.5 to 27.5 ± 10.4 ng/ml (+45.4%) in the VITD group and decreased from 16.9 ± 6.7 to 13.8 ± 6.0 ng/ml (-18.5%) in the placebo group (p < 0.001). In the VITD group, there was significant increase in muscle strength (+25.3%) of the lower limbs by chair rising test (p = 0.036). In women in the placebo group, there was considerable loss (-6.8%) in the lean mass (p = 0.030). CONCLUSION: The supplementation of vitamin D alone in postmenopausal women provided significant protective factor against the occurrence of sarcopenia, with significant increases in muscle strength and control of progressive loss of lean mass.
Entities:
Keywords:
Lean mass; Menopause; Muscle function; Vitamin D
Authors: Heike A Bischoff-Ferrari; Thomas Dietrich; E John Orav; Frank B Hu; Yuqing Zhang; Elisabeth W Karlson; Bess Dawson-Hughes Journal: Am J Clin Nutr Date: 2004-09 Impact factor: 7.045
Authors: Christian M Girgis; Roderick J Clifton-Bligh; Mark W Hamrick; Michael F Holick; Jenny E Gunton Journal: Endocr Rev Date: 2012-11-20 Impact factor: 19.871
Authors: Faustino R Pérez-López; Marc Brincat; C Tamer Erel; Florence Tremollieres; Marco Gambacciani; Irene Lambrinoudaki; Mette H Moen; Karin Schenck-Gustafsson; Svetlana Vujovic; Serge Rozenberg; Margaret Rees Journal: Maturitas Date: 2011-11-17 Impact factor: 4.342
Authors: Lisa Ceglia; Sathit Niramitmahapanya; Mauricio da Silva Morais; Donato A Rivas; Susan S Harris; Heike Bischoff-Ferrari; Roger A Fielding; Bess Dawson-Hughes Journal: J Clin Endocrinol Metab Date: 2013-10-09 Impact factor: 5.958
Authors: Steven Petak; Carmen G Barbu; Elaine W Yu; Roger Fielding; Kathleen Mulligan; Brian Sabowitz; Chih-Hsing Wu; John A Shepherd Journal: J Clin Densitom Date: 2013 Oct-Dec Impact factor: 2.617
Authors: F Landi; R Calvani; E Ortolani; S Salini; A M Martone; L Santoro; A Santoliquido; A Sisto; A Picca; E Marzetti Journal: Osteoporos Int Date: 2017-02-02 Impact factor: 4.507
Authors: J Nahas-Neto; L M Cangussu; C L Orsatti; F N Bueloni-Dias; P F Poloni; E B Schmitt; E A P Nahas Journal: Osteoporos Int Date: 2018-02-15 Impact factor: 4.507
Authors: Christian S Wright; Emma M Laing; Norman K Pollock; Dorothy B Hausman; Connie M Weaver; Berdine R Martin; George P McCabe; Munro Peacock; Stuart J Warden; Kathleen M Hill Gallant; Richard D Lewis Journal: J Bone Miner Res Date: 2018-08-27 Impact factor: 6.741