Adaptive Threshold Neural Spike Detector Using Stationary Wavelet Transform in CMOS.

Spike detection is an essential first step in the analysis of neural recordings. Detection at the frontend eases the bandwidth requirement for wireless data transfer of multichannel recordings to extra-cranial processing units. In this work, a low power digital integrated spike detector based on the lifting stationary wavelet transform is presented and developed. By monitoring the standard deviation of wavelet coefficients, the proposed detector can adaptively set a threshold value online for each channel independently without requiring user intervention. A prototype 16-channel spike detector was designed and tested in an FPGA. The method enables spike detection with nearly 90% accuracy even when the signal-to-noise ratio is as low as 2. The design was mapped to 130 nm CMOS technology and shown to occupy 0.014 mm(2) of area and dissipate 1.7 μW of power per channel, making it suitable for implantable multichannel neural recording systems.