| Literature DB >> 25955817 |
Jia Zhang1, Min Li1, Ya Yang1, Yan Yan2, Junhai Li3, Jingkun Qu2, Jiansheng Wang1.
Abstract
Natriuretic peptide receptor A (NPR-A) is the receptor for atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). NPR-A plays critical physiological and pathophysiological roles in several target cell and tissue system processes, such as cell growth, apoptosis, proliferation, and inflammation. Accumulating data demonstrate that NPR-A is involved in immune and inflammatory reactions and is a potential target in inflammation treatment. It is expressed in various cancer cells and is important for tumor growth. A recent study indicated that NPR-A signaling can regulate stem cell recruitment and angiogenesis. This signaling can serve as a model for studying the linkage between inflammation and tumorigenesis. In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation.Entities:
Mesh：
Substances：
Year: 2015 PMID： 25955817 DOI： 10.1615/critreveukaryotgeneexpr.2015012447
Source DB: PubMed Journal: Crit Rev Eukaryot Gene Expr ISSN： 1045-4403 Impact factor: 1.807