Literature DB >> 2595530

The correlation between cell survival curve and dose response curve of micronucleus (MN) frequency.

K Ono1, E Wandl, K Tsutsui, K Sasai, M Abe.   

Abstract

The correlation between cell survival curve and dose response curve of MN frequency following irradiations was studied using cytokinesis-block method. Both dose response curves were analyzed by linear quadratic model, i.e. SF = exp (-alpha D-beta D2) and MN frequency = aD + bD2 + C. A good correlation between alpha/beta and a/b ratios was observed in repeated paired experiments (= 0.97). When the cells were treated with BUdR, alpha-type radiosensitizer, a value in dose response curve of MN frequency increased but b value did not. These data present that MN frequency assay using cytokinesis-block method is available as a tool of rapid assay of radiosensitivity of cells.

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Year:  1989        PMID： 2595530

Source DB:  PubMed          Journal:  Strahlenther Onkol        ISSN： 0179-7158            Impact factor:   3.621


  10 in total

1.  An attempt to enhance chemosensitivity of quiescent cell populations in solid tumors by combined treatment with nicotinamide and carbogen.

Authors:  S Masunaga; K Ono; M Akaboshi; K Kawai; K Akuta; M Takagaki; M Suzuki; Y Kinashi; M Abe
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553

2.  Reduction of hypoxic cells in solid tumours induced by mild hyperthermia: special reference to differences in changes in the hypoxic fraction between total and quiescent cell populations.

Authors:  S Masunaga; K Ono; M Akaboshi; Y Nishimura; M Suzuki; Y Kinashi; M Takagaki; M Hiraoka; M Abe
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

3.  Micronuclei versus Chromosomal Aberrations Induced by X-Ray in Radiosensitive Mammalian Cells.

Authors:  Cristina Plamadeala; Andrzej Wojcik; Dorina Creanga
Journal:  Iran J Public Health       Date:  2015-03       Impact factor: 1.429

4.  Responses of total and quiescent cell populations in solid tumors to boron and gadolinium neutron capture reaction using neutrons with two different energy spectra.

Authors:  S Masunaga; K Ono; Y Sakurai; M Suzuki; M Takagaki; T Kobayashi; Y Kinashi; M Akaboshi
Journal:  Jpn J Cancer Res       Date:  1998-01

5.  Alteration of radiosensitivity of quiescent cell populations in solid tumors irradiated with X-rays twice at various intervals.

Authors:  S Masunaga; K Ono; M Mitsumori; M Abe
Journal:  Jpn J Cancer Res       Date:  1993-11

6.  Applicability of combination with tirapazamine in boron neutron capture therapy.

Authors:  S Masunaga; K Ono; Y Sakurai; H Hori; T Kobayashi; M Takagaki; M Suzuki; Y Kinashi; M Akaboshi
Journal:  Jpn J Cancer Res       Date:  1998-07

7.  Changes in the sensitivity of intratumor cells during fractionated tirapazamine administration.

Authors:  S Masunaga; K Ono; M Suzuki; Y Kinashi; M Takagaki; S Kasai; H Nagasawa; Y Uto; H Hori
Journal:  Jpn J Cancer Res       Date:  2000-07

8.  Usefulness of tirapazamine as a combined agent in chemoradiation and thermo-chemoradiation therapy at mild temperatures: reference to the effect on intratumor quiescent cells.

Authors:  S I Masunaga; K Ono; M Suzuki; Y Kinashi; M Takagaki; H Hori; S Kasai; H Nagasawa; Y Uto
Journal:  Jpn J Cancer Res       Date:  2000-05

9.  Augmentation in chemosensitivity of intratumor quiescent cells by combined treatment with nicotinamide and mild hyperthermia.

Authors:  S Masunaga; K Ono; M Akaboshi; K Kawai; M Suzuki; Y Kinashi; M Takagaki
Journal:  Jpn J Cancer Res       Date:  1997-08

10.  Effects of bioreductive agents, tirapazamine and mitomycin C, on quiescent cell populations in solid tumors, evaluated by micronucleus assay.

Authors:  S Masunaga; K Ono; H Hori; T Shibata; M Suzuki; Y Kinashi; M Takagaki; M Akaboshi
Journal:  Jpn J Cancer Res       Date:  1997-09
  10 in total

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