Maria Patrizia D'Errico1, Maria Fonte Petruzzelli2, Emilio A L Gianicolo3,4, Luca Grimaldi5, Francesco Loliva6, Francesco Tramacere2, Maria Grazia Andreassi3, Giorgio Pili5, Eugenio Picano3, Maurizio Portaluri2. 1. a Department of Laboratory Medicine , Brindisi , Italy. 2. b Department of Radiotherapy , "A. Perrino" Hospital , Brindisi , Italy. 3. c Institute of Clinical Physiology - National Research Council (IFC-CNR) , Pisa-Lecce , Italy. 4. f Johannes Gutenberg-Universität Mainz, Institut für Medizinische Biometrie, Epidemiologie und Informatik , Mainz , Germany. 5. d Department of Medical Physics "A. Perrino" Hospital , Brindisi , Italy. 6. e Department of Cardiology "Umberto I" Hospital , Fasano (Brindisi) , Italy.
Abstract
PURPOSE: To analyze temporal changes of B-type natriuretic peptide (BNP) used as index of heart remodeling in left-sided breast cancer patients after radiotherapy (RT) and its relationship with dosimetric parameters. METHODS AND MATERIALS: BNP and dose-volume parameters for heart and ventricle were collected in 59 patients (median age 58.0 years) during a 1-year follow-up. Biochemical measurements were performed before the RT treatment (T0), at 15 days during RT (T(15day)), at the end of RT (T(endRT)), and then at 1, 3, 6, 9, 12 months (T1, T3, T6, T9 and T12). A logistical regression analysis was performed to identify demographic characteristics, dosimetric variables and risk factors associated with increased values of BNP. RESULTS: The ratio between the BNP value at T12 and the BNP value at T0 (BNP(T12)/BNP(T0)) increased significantly (p < 0.01). A significant association was found between the variation of BNP values after 1 year and the isodose received by 50% of the volume (D50% [Gy]) both to the heart (p = 0.03) and ventricle (p = 0.04). CONCLUSIONS: BNP plasma levels could provide additional information about subclinical RT-induced cardiotoxicity earlier than traditional ecocardiographic data.
PURPOSE: To analyze temporal changes of B-type natriuretic peptide (BNP) used as index of heart remodeling in left-sided breast cancerpatients after radiotherapy (RT) and its relationship with dosimetric parameters. METHODS AND MATERIALS: BNP and dose-volume parameters for heart and ventricle were collected in 59 patients (median age 58.0 years) during a 1-year follow-up. Biochemical measurements were performed before the RT treatment (T0), at 15 days during RT (T(15day)), at the end of RT (T(endRT)), and then at 1, 3, 6, 9, 12 months (T1, T3, T6, T9 and T12). A logistical regression analysis was performed to identify demographic characteristics, dosimetric variables and risk factors associated with increased values of BNP. RESULTS: The ratio between the BNP value at T12 and the BNP value at T0 (BNP(T12)/BNP(T0)) increased significantly (p < 0.01). A significant association was found between the variation of BNP values after 1 year and the isodose received by 50% of the volume (D50% [Gy]) both to the heart (p = 0.03) and ventricle (p = 0.04). CONCLUSIONS:BNP plasma levels could provide additional information about subclinical RT-induced cardiotoxicity earlier than traditional ecocardiographic data.
Entities:
Keywords:
Radiotherapy; brain natriuretic peptide; breast cancer; cardiotoxicity; dosimetric parameters
Authors: Kyle Wang; Kevin A Pearlstein; Nicholas D Patchett; Allison M Deal; Panayiotis Mavroidis; Brian C Jensen; Matthew B Lipner; Timothy M Zagar; Yue Wang; Carrie B Lee; Michael J Eblan; Julian G Rosenman; Mark A Socinski; Thomas E Stinchcombe; Lawrence B Marks Journal: Radiother Oncol Date: 2017-10-16 Impact factor: 6.280
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